Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Jack Carson Taylor; Hilary W Heuer; Annie L Clark; Amy B Wise; Masood Manoochehri; Leah Forsberg; Carly Mester; Meghana Rao; Daniell Brushaber; Joel Kramer; Ariane E Welch; John Kornak; Walter Kremers; Brian Appleby; Bradford C Dickerson; Kimiko Domoto-Reilly; Julie A Fields; Nupur Ghoshal; Neill Graff-Radford; Murray Grossman; Matthew Gh Hall; Edward D Huey; David Irwin; Maria I Lapid; Irene Litvan; Ian R Mackenzie; Joseph C Masdeu; Mario F Mendez; Naomi Nevler; Chiadi U Onyike; Belen Pascual; Peter Pressman; Katherine P Rankin; Buddhika Ratnasiri; Julio C Rojas; Maria Carmela Tartaglia; Bonnie Wong; Maria Luisa Gorno-Tempini; Bradley F Boeve; Howard J Rosen; Adam L Boxer; Adam M Staffaroni

doi:10.1002/dad2.12423

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Jack Carson Taylor, Hilary W Heuer, Annie L Clark, Amy B Wise, Masood Manoochehri, Leah Forsberg, Carly Mester, Meghana Rao, Daniell Brushaber, Joel Kramer, Ariane E Welch, John Kornak, Walter Kremers, Brian Appleby, Bradford C Dickerson, Kimiko Domoto-Reilly, Julie A Fields, Nupur Ghoshal, Neill Graff-Radford, Murray GrossmanMatthew Gh Hall, Edward D Huey, David Irwin, Maria I Lapid, Irene Litvan, Ian R Mackenzie, Joseph C Masdeu, Mario F Mendez, Naomi Nevler, Chiadi U Onyike, Belen Pascual, Peter Pressman, Katherine P Rankin, Buddhika Ratnasiri, Julio C Rojas, Maria Carmela Tartaglia, Bonnie Wong, Maria Luisa Gorno-Tempini, Bradley F Boeve, Howard J Rosen, Adam L Boxer, Adam M Staffaroni

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp).

METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [ N = 101]; prodromal: 0.5 [ N = 49]; symptomatic ≥1 [ N = 51]; not measured [ N = 13]) were asked to complete ALLFTD-mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys.

RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests.

DISCUSSION: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research.

HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses.

Original language	English (US)
Pages (from-to)	e12423
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	15
Issue number	2
DOIs	https://doi.org/10.1002/dad2.12423
State	Published - 2023

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Taylor, J. C., Heuer, H. W., Clark, A. L., Wise, A. B., Manoochehri, M., Forsberg, L., Mester, C., Rao, M., Brushaber, D., Kramer, J., Welch, A. E., Kornak, J., Kremers, W., Appleby, B., Dickerson, B. C., Domoto-Reilly, K., Fields, J. A., Ghoshal, N., Graff-Radford, N., ... Staffaroni, A. M. (2023). Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(2), e12423. https://doi.org/10.1002/dad2.12423

Taylor, JC, Heuer, HW, Clark, AL, Wise, AB, Manoochehri, M, Forsberg, L, Mester, C, Rao, M, Brushaber, D, Kramer, J, Welch, AE, Kornak, J, Kremers, W, Appleby, B, Dickerson, BC, Domoto-Reilly, K, Fields, JA, Ghoshal, N, Graff-Radford, N, Grossman, M, Hall, MG, Huey, ED, Irwin, D, Lapid, MI, Litvan, I, Mackenzie, IR, Masdeu, JC, Mendez, MF, Nevler, N, Onyike, CU, Pascual, B, Pressman, P, Rankin, KP, Ratnasiri, B, Rojas, JC, Tartaglia, MC, Wong, B, Gorno-Tempini, ML, Boeve, BF, Rosen, HJ, Boxer, AL & Staffaroni, AM 2023, 'Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 15, no. 2, pp. e12423. https://doi.org/10.1002/dad2.12423

@article{893a2c3902a5489e98626165eb6304b4,

title = "Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research",

abstract = "INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp).METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR{\textregistered}+NACC-FTLD = 0 [ N = 101]; prodromal: 0.5 [ N = 49]; symptomatic ≥1 [ N = 51]; not measured [ N = 13]) were asked to complete ALLFTD-mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests.DISCUSSION: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research.HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses.",

author = "Taylor, {Jack Carson} and Heuer, {Hilary W} and Clark, {Annie L} and Wise, {Amy B} and Masood Manoochehri and Leah Forsberg and Carly Mester and Meghana Rao and Daniell Brushaber and Joel Kramer and Welch, {Ariane E} and John Kornak and Walter Kremers and Brian Appleby and Dickerson, {Bradford C} and Kimiko Domoto-Reilly and Fields, {Julie A} and Nupur Ghoshal and Neill Graff-Radford and Murray Grossman and Hall, {Matthew Gh} and Huey, {Edward D} and David Irwin and Lapid, {Maria I} and Irene Litvan and Mackenzie, {Ian R} and Masdeu, {Joseph C} and Mendez, {Mario F} and Naomi Nevler and Onyike, {Chiadi U} and Belen Pascual and Peter Pressman and Rankin, {Katherine P} and Buddhika Ratnasiri and Rojas, {Julio C} and Tartaglia, {Maria Carmela} and Bonnie Wong and Gorno-Tempini, {Maria Luisa} and Boeve, {Bradley F} and Rosen, {Howard J} and Boxer, {Adam L} and Staffaroni, {Adam M}",

note = "{\textcopyright} 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2023",

doi = "10.1002/dad2.12423",

language = "English (US)",

volume = "15",

pages = "e12423",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

AU - Taylor, Jack Carson

AU - Heuer, Hilary W

AU - Clark, Annie L

AU - Wise, Amy B

AU - Manoochehri, Masood

AU - Forsberg, Leah

AU - Mester, Carly

AU - Rao, Meghana

AU - Brushaber, Daniell

AU - Kramer, Joel

AU - Welch, Ariane E

AU - Kornak, John

AU - Kremers, Walter

AU - Appleby, Brian

AU - Dickerson, Bradford C

AU - Domoto-Reilly, Kimiko

AU - Fields, Julie A

AU - Ghoshal, Nupur

AU - Graff-Radford, Neill

AU - Grossman, Murray

AU - Hall, Matthew Gh

AU - Huey, Edward D

AU - Irwin, David

AU - Lapid, Maria I

AU - Litvan, Irene

AU - Mackenzie, Ian R

AU - Masdeu, Joseph C

AU - Mendez, Mario F

AU - Nevler, Naomi

AU - Onyike, Chiadi U

AU - Pascual, Belen

AU - Pressman, Peter

AU - Rankin, Katherine P

AU - Ratnasiri, Buddhika

AU - Rojas, Julio C

AU - Tartaglia, Maria Carmela

AU - Wong, Bonnie

AU - Gorno-Tempini, Maria Luisa

AU - Boeve, Bradley F

AU - Rosen, Howard J

AU - Boxer, Adam L

AU - Staffaroni, Adam M

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp).METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [ N = 101]; prodromal: 0.5 [ N = 49]; symptomatic ≥1 [ N = 51]; not measured [ N = 13]) were asked to complete ALLFTD-mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests.DISCUSSION: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research.HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses.

AB - INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp).METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [ N = 101]; prodromal: 0.5 [ N = 49]; symptomatic ≥1 [ N = 51]; not measured [ N = 13]) were asked to complete ALLFTD-mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests.DISCUSSION: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research.HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses.

U2 - 10.1002/dad2.12423

DO - 10.1002/dad2.12423

M3 - Article

C2 - 37180971

SN - 2352-8729

VL - 15

SP - e12423

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 2

ER -

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

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