TY - JOUR
T1 - Food, nutrition, and fertility
T2 - from soil to fork
AU - Maitin-Shepard, Melissa
AU - Werner, Erika F.
AU - Feig, Larry A.
AU - Chavarro, Jorge E.
AU - Mumford, Sunni L.
AU - Wylie, Blair
AU - Rando, Oliver J.
AU - Gaskins, Audrey J.
AU - Sakkas, Denny
AU - Arora, Manish
AU - Kudesia, Rashmi
AU - Lujan, Marla E.
AU - Braun, Joseph
AU - Mozaffarian, Dariush
N1 - Funding Information:
Support for the development of this report and the scientific meeting on which it is based was provided by a grant to Tufts University from the Bia-Echo Foundation . A representative from the sponsor attended the meeting. The sponsor had no involvement in the planning or execution of the meeting or the development of this meeting report.
Funding Information:
MMS reports financial support and travel were provided by Tufts University. JEC reports a relationship with Doveras Inc. that includes: board membership; reports a relationship with Tufts University that includes: speaking and lecture fees; reports a relationship with National Institutes of Health that includes: consulting or advisory; reports a relationship with University of Nebraska-Lincoln that includes: speaking and lecture fees and travel reimbursement; reports a relationship with the Johns Hopkins University School of Medicine that includes: speaking and lecture fees and travel reimbursement; reports a relationship with Maine Medical Center that includes: consulting or advisory; reports a relationship with Pacific Coast Reproductive Society that includes: speaking and lecture fees and travel reimbursement; and reports a relationship with American Society for Reproductive Medicine Birmingham that includes: speaking and lecture fees. OR reports a relationship with National Institutes of Health that includes: funding grants. AG reports financial support was provided by National Institute of Environmental Health Sciences and reports a relationship with Doveras Fertility, Inc. that includes: equity or stocks. MA reports a relationship with Linus Biotechnology Inc that includes: board membership, employment, and equity or stocks. JB was compensated for serving as an expert witness on behalf of plaintiffs in litigation related to PFAS-contaminated drinking water. DM reports a relationship with National Institutes of Health that includes: funding grants; reports a relationship with Gates Foundation that includes: funding grants; reports a relationship with The Rockefeller Foundation that includes: funding grants; reports a relationship with Vail Innovative Global Research that includes: funding grants; reports a relationship with Kaiser Permanente Fund at East Bay Community Foundation that includes: funding grants; reports a relationship with Acasti Pharma Inc that includes: consulting or advisory; reports a relationship with Beren Therapeutics that includes: consulting or advisory; reports a relationship with Brightseed that includes: consulting or advisory; reports a relationship with Calibrate that includes: consulting or advisory and equity or stocks; reports a relationship with Elysium Health that includes: consulting or advisory; reports a relationship with Filtricine that includes: consulting or advisory; reports a relationship with HumanCo that includes: consulting or advisory and equity or stocks; reports a relationship with Instacart Health that includes: consulting or advisory; reports a relationship with January Inc that includes: consulting or advisory; reports a relationship with Season Health that includes: consulting or advisory; and reports a relationship with UpToDate that includes: consulting or advisory. All other authors report no conflicts of interest.
Publisher Copyright:
© 2023
PY - 2024/2
Y1 - 2024/2
N2 - Food and nutrition-related factors, including foods and nutrients consumed, dietary patterns, use of dietary supplements, adiposity, and exposure to food-related environmental contaminants, have the potential to impact semen quality and male and female fertility; obstetric, fetal, and birth outcomes; and the health of future generations, but gaps in evidence remain. On 9 November 2022, Tufts University's Friedman School of Nutrition Science and Policy and the school's Food and Nutrition Innovation Institute hosted a 1-d meeting to explore the evidence and evidence gaps regarding the relationships between food, nutrition, and fertility. Topics addressed included male fertility, female fertility and gestation, and intergenerational effects. This meeting report summarizes the presentations and deliberations from the meeting. Regarding male fertility, a positive association exists with a healthy dietary pattern, with high-quality evidence for semen quality and lower quality evidence for clinical outcomes. Folic acid and zinc supplementation have been found to not impact male fertility. In females, body weight status and other nutrition-related factors are linked to nearly half of all ovulation disorders, a leading cause of female infertility. Females with obesity have worse fertility treatment, pregnancy-related, and birth outcomes. Environmental contaminants found in food, water, or its packaging, including lead, perfluorinated alkyl substances, phthalates, and phenols, adversely impact female reproductive outcomes. Epigenetic research has found that maternal and paternal dietary-related factors can impact outcomes for future generations. Priority evidence gaps identified by meeting participants relate to the effects of nutrition and dietary patterns on fertility, gaps in communication regarding fertility optimization through changes in nutritional and environmental exposures, and interventions impacting germ cell mechanisms through dietary effects. Participants developed research proposals to address the priority evidence gaps. The workshop findings serve as a foundation for future prioritization of scientific research to address evidence gaps related to food, nutrition, and fertility.
AB - Food and nutrition-related factors, including foods and nutrients consumed, dietary patterns, use of dietary supplements, adiposity, and exposure to food-related environmental contaminants, have the potential to impact semen quality and male and female fertility; obstetric, fetal, and birth outcomes; and the health of future generations, but gaps in evidence remain. On 9 November 2022, Tufts University's Friedman School of Nutrition Science and Policy and the school's Food and Nutrition Innovation Institute hosted a 1-d meeting to explore the evidence and evidence gaps regarding the relationships between food, nutrition, and fertility. Topics addressed included male fertility, female fertility and gestation, and intergenerational effects. This meeting report summarizes the presentations and deliberations from the meeting. Regarding male fertility, a positive association exists with a healthy dietary pattern, with high-quality evidence for semen quality and lower quality evidence for clinical outcomes. Folic acid and zinc supplementation have been found to not impact male fertility. In females, body weight status and other nutrition-related factors are linked to nearly half of all ovulation disorders, a leading cause of female infertility. Females with obesity have worse fertility treatment, pregnancy-related, and birth outcomes. Environmental contaminants found in food, water, or its packaging, including lead, perfluorinated alkyl substances, phthalates, and phenols, adversely impact female reproductive outcomes. Epigenetic research has found that maternal and paternal dietary-related factors can impact outcomes for future generations. Priority evidence gaps identified by meeting participants relate to the effects of nutrition and dietary patterns on fertility, gaps in communication regarding fertility optimization through changes in nutritional and environmental exposures, and interventions impacting germ cell mechanisms through dietary effects. Participants developed research proposals to address the priority evidence gaps. The workshop findings serve as a foundation for future prioritization of scientific research to address evidence gaps related to food, nutrition, and fertility.
KW - dietary patterns
KW - dietary supplements
KW - environmental exposures
KW - fertility
KW - in vitro fertilization
KW - intergenerational health
KW - obesity
KW - polycystic ovary syndrome
KW - pregnancy
KW - Humans
KW - Semen Analysis
KW - Male
KW - Pregnancy
KW - Fertility
KW - Soil
KW - Female
KW - Research Design
KW - Dietary Supplements
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U2 - 10.1016/j.ajcnut.2023.12.005
DO - 10.1016/j.ajcnut.2023.12.005
M3 - Article
C2 - 38101699
AN - SCOPUS:85181252573
SN - 0002-9165
VL - 119
SP - 578
EP - 589
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -