TY - JOUR
T1 - Free-breathing multitasking multi-echo MRI for whole-liver water-specific T1, proton density fat fraction, and R2∗ quantification
AU - Wang, Nan
AU - Cao, Tianle
AU - Han, Fei
AU - Xie, Yibin
AU - Zhong, Xiaodong
AU - Ma, Sen
AU - Kwan, Alan
AU - Fan, Zhaoyang
AU - Han, Hui
AU - Bi, Xiaoming
AU - Noureddin, Mazen
AU - Deshpande, Vibhas
AU - Christodoulou, Anthony G.
AU - Li, Debiao
N1 - Publisher Copyright:
© 2021 International Society for Magnetic Resonance in Medicine
PY - 2022/1
Y1 - 2022/1
N2 - Purpose: To develop a 3D multitasking multi-echo (MT-ME) technique for the comprehensive characterization of liver tissues with 5-min free-breathing acquisition; whole-liver coverage; a spatial resolution of 1.5 × 1.5 × 6 mm3; and simultaneous quantification of T1, water-specific T1 (T1w), proton density fat fraction (PDFF), and (Formula presented.). Methods: Six-echo bipolar spoiled gradient echo readouts following inversion recovery preparation was performed to generate T1, water/fat, and (Formula presented.) contrast. MR multitasking was used to reconstruct the MT-ME images with 3 spatial dimensions: 1 T1 recovery dimension, 1 multi-echo dimension, and 1 respiratory dimension. A basis function–based approach was developed for T1w quantification, followed by the estimation of (Formula presented.) and T1-corrected PDFF. The intrasession repeatability and agreement against references of MT-ME measurements were tested on a phantom and 15 clinically healthy subjects. In addition, 4 patients with confirmed liver diseases were recruited, and the agreement between MT-ME measurements and references was assessed. Results: MT-ME produced high-quality, coregistered T1, T1w, PDFF, and (Formula presented.) maps with good intrasession repeatability and substantial agreement with references on phantom and human studies. The intra-class coefficients of T1, T1w, PDFF, and (Formula presented.) from the repeat MT-ME measurements on clinically healthy subjects were 0.989, 0.990, 0.999, and 0.988, respectively. The intra-class coefficients of T1, PDFF, and (Formula presented.) between the MT-ME and reference measurements were 0.924, 0.987, and 0.975 in healthy subjects and 0.980, 0.999, and 0.998 in patients. The T1w was independent to PDFF (R = −0.029, P =.904). Conclusion: The proposed MT-ME technique quantifies T1, T1w, PDFF, and (Formula presented.) simultaneously and is clinically promising for the comprehensive characterization of liver tissue properties.
AB - Purpose: To develop a 3D multitasking multi-echo (MT-ME) technique for the comprehensive characterization of liver tissues with 5-min free-breathing acquisition; whole-liver coverage; a spatial resolution of 1.5 × 1.5 × 6 mm3; and simultaneous quantification of T1, water-specific T1 (T1w), proton density fat fraction (PDFF), and (Formula presented.). Methods: Six-echo bipolar spoiled gradient echo readouts following inversion recovery preparation was performed to generate T1, water/fat, and (Formula presented.) contrast. MR multitasking was used to reconstruct the MT-ME images with 3 spatial dimensions: 1 T1 recovery dimension, 1 multi-echo dimension, and 1 respiratory dimension. A basis function–based approach was developed for T1w quantification, followed by the estimation of (Formula presented.) and T1-corrected PDFF. The intrasession repeatability and agreement against references of MT-ME measurements were tested on a phantom and 15 clinically healthy subjects. In addition, 4 patients with confirmed liver diseases were recruited, and the agreement between MT-ME measurements and references was assessed. Results: MT-ME produced high-quality, coregistered T1, T1w, PDFF, and (Formula presented.) maps with good intrasession repeatability and substantial agreement with references on phantom and human studies. The intra-class coefficients of T1, T1w, PDFF, and (Formula presented.) from the repeat MT-ME measurements on clinically healthy subjects were 0.989, 0.990, 0.999, and 0.988, respectively. The intra-class coefficients of T1, PDFF, and (Formula presented.) between the MT-ME and reference measurements were 0.924, 0.987, and 0.975 in healthy subjects and 0.980, 0.999, and 0.998 in patients. The T1w was independent to PDFF (R = −0.029, P =.904). Conclusion: The proposed MT-ME technique quantifies T1, T1w, PDFF, and (Formula presented.) simultaneously and is clinically promising for the comprehensive characterization of liver tissue properties.
KW - MR multitasking
KW - free-breathing acquisition
KW - liver T/PDFF/R2∗ mapping
KW - low-rank tensor
KW - water-specific T
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U2 - 10.1002/mrm.28970
DO - 10.1002/mrm.28970
M3 - Article
C2 - 34418152
AN - SCOPUS:85113132593
SN - 0740-3194
VL - 87
SP - 120
EP - 137
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 1
ER -