Gene transfer in haematological malignancy

Malcolm K. Brenner

doi:10.3109/07853899608999113

Gene transfer in haematological malignancy

Malcolm K. Brenner

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Although gene transfer was first suggested to treat inherited monogenic disorders, at present most clinical protocols are intended to treat patients with malignant disease. Although current vector technologies profoundly limit the potential therapeutic applications of gene transfer, the technique is already being successfully used to complement longer established therapies. This article reviews current and forthcoming applications of gene transfer to treat haematological malignancies.

Original language	English (US)
Pages (from-to)	491-497
Number of pages	7
Journal	Annals of Medicine
Volume	28
Issue number	6
DOIs	https://doi.org/10.3109/07853899608999113
State	Published - 1996

Keywords

Cytotoxic T cells
Gene therapy
Haematological malignancies
Haematopoietic stem cells
Vectors

ASJC Scopus subject areas

Medicine(all)

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10.3109/07853899608999113

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title = "Gene transfer in haematological malignancy",

abstract = "Although gene transfer was first suggested to treat inherited monogenic disorders, at present most clinical protocols are intended to treat patients with malignant disease. Although current vector technologies profoundly limit the potential therapeutic applications of gene transfer, the technique is already being successfully used to complement longer established therapies. This article reviews current and forthcoming applications of gene transfer to treat haematological malignancies.",

keywords = "Cytotoxic T cells, Gene therapy, Haematological malignancies, Haematopoietic stem cells, Vectors",

author = "Brenner, {Malcolm K.}",

note = "Funding Information: Some of the work described in this article was supported by the National Institutes of Health grant CA 201 80, Cancer Centre Support CORE Grant CA 21 765, and by the American Lebanese Syrian Associated Charities (ALSAC). I would like to thank Genetic Therapy, Inc. for providing the clinical grade vectors described in the section on gene marking, and Nancy Parnell for word-processing.",

year = "1996",

doi = "10.3109/07853899608999113",

language = "English (US)",

volume = "28",

pages = "491--497",

journal = "Annals of Medicine",

issn = "0785-3890",

publisher = "Informa Healthcare",

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T1 - Gene transfer in haematological malignancy

AU - Brenner, Malcolm K.

N1 - Funding Information: Some of the work described in this article was supported by the National Institutes of Health grant CA 201 80, Cancer Centre Support CORE Grant CA 21 765, and by the American Lebanese Syrian Associated Charities (ALSAC). I would like to thank Genetic Therapy, Inc. for providing the clinical grade vectors described in the section on gene marking, and Nancy Parnell for word-processing.

PY - 1996

Y1 - 1996

N2 - Although gene transfer was first suggested to treat inherited monogenic disorders, at present most clinical protocols are intended to treat patients with malignant disease. Although current vector technologies profoundly limit the potential therapeutic applications of gene transfer, the technique is already being successfully used to complement longer established therapies. This article reviews current and forthcoming applications of gene transfer to treat haematological malignancies.

AB - Although gene transfer was first suggested to treat inherited monogenic disorders, at present most clinical protocols are intended to treat patients with malignant disease. Although current vector technologies profoundly limit the potential therapeutic applications of gene transfer, the technique is already being successfully used to complement longer established therapies. This article reviews current and forthcoming applications of gene transfer to treat haematological malignancies.

KW - Cytotoxic T cells

KW - Gene therapy

KW - Haematological malignancies

KW - Haematopoietic stem cells

KW - Vectors

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U2 - 10.3109/07853899608999113

DO - 10.3109/07853899608999113

M3 - Review article

C2 - 9017108

AN - SCOPUS:0030450434

SN - 0785-3890

VL - 28

SP - 491

EP - 497

JO - Annals of Medicine

JF - Annals of Medicine

IS - 6

ER -

Gene transfer in haematological malignancy

Abstract

Keywords

ASJC Scopus subject areas

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