Genetic ataxia

Alberto L. Rosa; Tetsuo Ashizawa

doi:10.1016/S0733-8619(02)00008-7

Genetic ataxia

Alberto L. Rosa, Tetsuo Ashizawa

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Advances in molecular genetics have led to identification of an increasing number of genes responsible for inherited ataxic disorders. Consequently, DNA testing has become a powerful method to unambiguously establish the diagnosis in some of these disorders; however, there are limitations in this approach. Furthermore, the ethical, social, legal and psychological implications of the genetic test results are complex, necessitating appropriate counseling. This article intends to help the practicing neurologist clinically differentiate these disorders, choose appropriate genetic tests, and recognize the importance of counseling.

Original language	English (US)
Pages (from-to)	727-757
Number of pages	31
Journal	Neurologic Clinics
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/S0733-8619(02)00008-7
State	Published - Aug 2002

ASJC Scopus subject areas

Clinical Neurology

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10.1016/S0733-8619(02)00008-7

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title = "Genetic ataxia",

abstract = "Advances in molecular genetics have led to identification of an increasing number of genes responsible for inherited ataxic disorders. Consequently, DNA testing has become a powerful method to unambiguously establish the diagnosis in some of these disorders; however, there are limitations in this approach. Furthermore, the ethical, social, legal and psychological implications of the genetic test results are complex, necessitating appropriate counseling. This article intends to help the practicing neurologist clinically differentiate these disorders, choose appropriate genetic tests, and recognize the importance of counseling.",

author = "Rosa, {Alberto L.} and Tetsuo Ashizawa",

note = "Funding Information: Work in the laboratory of TA has been supported by NIH/NINDS grant #1 RO1 NS41547-01. Work in the laboratory of ALR has been supported by Grants from CONICET, SETCIP and Fundacion Antorchas (Argentina), Association Francaise contre les Myopathies (AFM, France) and the International Program of the Howard Hughes Medical Institute (HHMI, USA). ",

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T1 - Genetic ataxia

AU - Rosa, Alberto L.

AU - Ashizawa, Tetsuo

N1 - Funding Information: Work in the laboratory of TA has been supported by NIH/NINDS grant #1 RO1 NS41547-01. Work in the laboratory of ALR has been supported by Grants from CONICET, SETCIP and Fundacion Antorchas (Argentina), Association Francaise contre les Myopathies (AFM, France) and the International Program of the Howard Hughes Medical Institute (HHMI, USA).

PY - 2002/8

Y1 - 2002/8

N2 - Advances in molecular genetics have led to identification of an increasing number of genes responsible for inherited ataxic disorders. Consequently, DNA testing has become a powerful method to unambiguously establish the diagnosis in some of these disorders; however, there are limitations in this approach. Furthermore, the ethical, social, legal and psychological implications of the genetic test results are complex, necessitating appropriate counseling. This article intends to help the practicing neurologist clinically differentiate these disorders, choose appropriate genetic tests, and recognize the importance of counseling.

AB - Advances in molecular genetics have led to identification of an increasing number of genes responsible for inherited ataxic disorders. Consequently, DNA testing has become a powerful method to unambiguously establish the diagnosis in some of these disorders; however, there are limitations in this approach. Furthermore, the ethical, social, legal and psychological implications of the genetic test results are complex, necessitating appropriate counseling. This article intends to help the practicing neurologist clinically differentiate these disorders, choose appropriate genetic tests, and recognize the importance of counseling.

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JO - Neurologic Clinics

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Genetic ataxia

Abstract

ASJC Scopus subject areas

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