Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel; James I. Mullins; Gerald H. Learn; Laura Manns-Arcuino; Belinda L. Herring; Marcia L. Kalish; Richard W. Steketee; Donald M. Thea; Joan E. Nichols; Shan Lu Liu; Abdallah Harmache; Xi He; David Muthui; Anup Madan; Leroy Hood; Ashley T. Haase; Mary Zupancic; Katherine Staskus; Steven Wolinsky; Paul Krogstad; Jia Qi Zhao; Irvin Chen; Richard Koup; David Ho; Bette Korber; Raymond J. Apple; Robert W. Coombs; Savita Pahwa; Norbert J. Roberts

doi:10.1126/science.280.5366.1073

Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel, James I. Mullins, Gerald H. Learn, Laura Manns-Arcuino, Belinda L. Herring, Marcia L. Kalish, Richard W. Steketee, Donald M. Thea, Joan E. Nichols, Shan Lu Liu, Abdallah Harmache, Xi He, David Muthui, Anup Madan, Leroy Hood, Ashley T. Haase, Mary Zupancic, Katherine Staskus, Steven Wolinsky, Paul KrogstadJia Qi Zhao, Irvin Chen, Richard Koup, David Ho, Bette Korber, Raymond J. Apple, Robert W. Coombs, Savita Pahwa, Norbert J. Roberts

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Abstract

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

Original language	English (US)
Pages (from-to)	1073-1077
Number of pages	5
Journal	Science
Volume	280
Issue number	5366
DOIs	https://doi.org/10.1126/science.280.5366.1073
State	Published - May 15 1998

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Frenkel, L. M., Mullins, J. I., Learn, G. H., Manns-Arcuino, L., Herring, B. L., Kalish, M. L., Steketee, R. W., Thea, D. M., Nichols, J. E., Liu, S. L., Harmache, A., He, X., Muthui, D., Madan, A., Hood, L., Haase, A. T., Zupancic, M., Staskus, K., Wolinsky, S., ... Roberts, N. J. (1998). Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science, 280(5366), 1073-1077. https://doi.org/10.1126/science.280.5366.1073

Frenkel, LM, Mullins, JI, Learn, GH, Manns-Arcuino, L, Herring, BL, Kalish, ML, Steketee, RW, Thea, DM, Nichols, JE, Liu, SL, Harmache, A, He, X, Muthui, D, Madan, A, Hood, L, Haase, AT, Zupancic, M, Staskus, K, Wolinsky, S, Krogstad, P, Zhao, JQ, Chen, I, Koup, R, Ho, D, Korber, B, Apple, RJ, Coombs, RW, Pahwa, S & Roberts, NJ 1998, 'Genetic evaluation of suspected cases of transient HIV-1 infection of infants', Science, vol. 280, no. 5366, pp. 1073-1077. https://doi.org/10.1126/science.280.5366.1073

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title = "Genetic evaluation of suspected cases of transient HIV-1 infection of infants",

abstract = "Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.",

author = "Frenkel, {Lisa M.} and Mullins, {James I.} and Learn, {Gerald H.} and Laura Manns-Arcuino and Herring, {Belinda L.} and Kalish, {Marcia L.} and Steketee, {Richard W.} and Thea, {Donald M.} and Nichols, {Joan E.} and Liu, {Shan Lu} and Abdallah Harmache and Xi He and David Muthui and Anup Madan and Leroy Hood and Haase, {Ashley T.} and Mary Zupancic and Katherine Staskus and Steven Wolinsky and Paul Krogstad and Zhao, {Jia Qi} and Irvin Chen and Richard Koup and David Ho and Bette Korber and Apple, {Raymond J.} and Coombs, {Robert W.} and Savita Pahwa and Roberts, {Norbert J.}",

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doi = "10.1126/science.280.5366.1073",

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AU - Frenkel, Lisa M.

AU - Mullins, James I.

AU - Learn, Gerald H.

AU - Manns-Arcuino, Laura

AU - Herring, Belinda L.

AU - Kalish, Marcia L.

AU - Steketee, Richard W.

AU - Thea, Donald M.

AU - Nichols, Joan E.

AU - Liu, Shan Lu

AU - Harmache, Abdallah

AU - He, Xi

AU - Muthui, David

AU - Madan, Anup

AU - Hood, Leroy

AU - Haase, Ashley T.

AU - Zupancic, Mary

AU - Staskus, Katherine

AU - Wolinsky, Steven

AU - Krogstad, Paul

AU - Zhao, Jia Qi

AU - Chen, Irvin

AU - Koup, Richard

AU - Ho, David

AU - Korber, Bette

AU - Apple, Raymond J.

AU - Coombs, Robert W.

AU - Pahwa, Savita

AU - Roberts, Norbert J.

PY - 1998/5/15

Y1 - 1998/5/15

N2 - Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

AB - Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

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Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Abstract

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