TY - JOUR
T1 - Genomic instability in chronic obstructive pulmonary disease and lung cancer
T2 - A systematic review and meta-analysis of studies using the micronucleus assay
AU - Asanov, Maxim
AU - Bonassi, Stefano
AU - Proietti, Stefania
AU - Minina, Varvara I.
AU - Tomino, Carlo
AU - El-Zein, Randa
N1 - Funding Information:
This work was supported by funding of the Italian Ministry of Health [ricerca corrente]. MA was supported by a fellowship awarded by the Department of State Youth Policy and Social Projects in Higher Education of the Ministry of Science and Higher Education of the Russian Federation (Academic year 2019/2020; n. MH-24/3195). The work of REZ was supported by the following grants: CA216426 , NIH/NCI and CA189240 , NIH/NCI .
Funding Information:
This work was supported by funding of the Italian Ministry of Health [ricerca corrente]. MA was supported by a fellowship awarded by the Department of State Youth Policy and Social Projects in Higher Education of the Ministry of Science and Higher Education of the Russian Federation (Academic year 2019/2020; n. MH-24/3195). The work of REZ was supported by the following grants: CA216426, NIH/NCI and CA189240, NIH/NCI.
Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Respiratory tissues are highly susceptible to diseases due to the constant exposure to physical and chemical airborne pollutants. Chronic obstructive pulmonary disease (COPD) and lung cancer are among the most common causes of serious illness and death worldwide. The inflammatory environment associated with these respiratory diseases has long been accepted as the major player in the development of airway abnormalities. The presence and relevance of DNA damage and genomic instability makes the micronucleus assay a suitable candidate to quantitatively estimate these early pathogenetic events. A systematic review and meta-analysis were planned to determine underlying common mechanisms that can explain the relationships between COPD and lung cancer. A total of 17 studies from Jan 1999 to Dec 2019 comparing micronucleus frequency in patients affected by respiratory diseases vs healthy controls were analysed. Our results confirmed the presence of significant association between MN frequency and the diseases investigated, and suggested a circle of events linking inflammation induced oxidative stress to the risk of disease through genomic instability and hypoxia. Therefore, using non-invasive, robust and cost effective genomic instability assays such as the micronucleus assay, would allow us to capture unique phenotypic and biological changes that would allow the identification of subjects at high risk of developing lung diseases and improve early detection strategies.
AB - Respiratory tissues are highly susceptible to diseases due to the constant exposure to physical and chemical airborne pollutants. Chronic obstructive pulmonary disease (COPD) and lung cancer are among the most common causes of serious illness and death worldwide. The inflammatory environment associated with these respiratory diseases has long been accepted as the major player in the development of airway abnormalities. The presence and relevance of DNA damage and genomic instability makes the micronucleus assay a suitable candidate to quantitatively estimate these early pathogenetic events. A systematic review and meta-analysis were planned to determine underlying common mechanisms that can explain the relationships between COPD and lung cancer. A total of 17 studies from Jan 1999 to Dec 2019 comparing micronucleus frequency in patients affected by respiratory diseases vs healthy controls were analysed. Our results confirmed the presence of significant association between MN frequency and the diseases investigated, and suggested a circle of events linking inflammation induced oxidative stress to the risk of disease through genomic instability and hypoxia. Therefore, using non-invasive, robust and cost effective genomic instability assays such as the micronucleus assay, would allow us to capture unique phenotypic and biological changes that would allow the identification of subjects at high risk of developing lung diseases and improve early detection strategies.
KW - COPD
KW - Inflammation
KW - Lung cancer
KW - Micronucleus assay
KW - Oxidative stress
KW - Micronucleus Tests/methods
KW - Pulmonary Disease, Chronic Obstructive/genetics
KW - Humans
KW - Lung Neoplasms/genetics
KW - Genomic Instability/genetics
KW - Oxidative Stress/genetics
KW - Animals
KW - Inflammation/genetics
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U2 - 10.1016/j.mrrev.2020.108344
DO - 10.1016/j.mrrev.2020.108344
M3 - Review article
C2 - 34083053
AN - SCOPUS:85097089846
SN - 1383-5742
VL - 787
SP - 108344
JO - Mutation Research - Reviews in Mutation Research
JF - Mutation Research - Reviews in Mutation Research
M1 - 108344
ER -