TY - GEN
T1 - Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light
AU - Judy, Millard M.
AU - Matthews, James L.
AU - Boriak, Richard L.
AU - Burlacu, A.
AU - Lewis, Dorothy E.
AU - et.al.,
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - We have newly designed and synthesized a class of photochemical 1,8-naphthalimide dyes. Photochemical investigation strongly suggests that these dyes function as photoalkylation agents following activation to an intermediate state by visible light (circa 420 nm) excitation. The activated species reacts readily with nucleophilic amino acid residues; e.g., tryptophan, tyrosine, cysteine, and methionine. One such dye, 1,14-bis(N-hexyl-3′-bromo- 1,8′-naphthalimid-4′-yl)-1,4,11,14-tetraazatetradecane-5,10-d ione, incorporating two reactive 1,8-naphthalimide groups at each end of an intervening structural bridge has been used to achieve photochemical or photoactivated bonding (welding) of collagenous dura mater sheets to each other. Weld shear strengths of up to 425 gm/cm2 (1.14 × 104 Nt/m2) have been obtained.
AB - We have newly designed and synthesized a class of photochemical 1,8-naphthalimide dyes. Photochemical investigation strongly suggests that these dyes function as photoalkylation agents following activation to an intermediate state by visible light (circa 420 nm) excitation. The activated species reacts readily with nucleophilic amino acid residues; e.g., tryptophan, tyrosine, cysteine, and methionine. One such dye, 1,14-bis(N-hexyl-3′-bromo- 1,8′-naphthalimid-4′-yl)-1,4,11,14-tetraazatetradecane-5,10-d ione, incorporating two reactive 1,8-naphthalimide groups at each end of an intervening structural bridge has been used to achieve photochemical or photoactivated bonding (welding) of collagenous dura mater sheets to each other. Weld shear strengths of up to 425 gm/cm2 (1.14 × 104 Nt/m2) have been obtained.
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U2 - 10.1117/12.147028
DO - 10.1117/12.147028
M3 - Conference contribution
AN - SCOPUS:0027154399
SN - 0819411035
SN - 9780819411037
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 175
EP - 179
BT - Proceedings of SPIE - The International Society for Optical Engineering
PB - Publ by Society of Photo-Optical Instrumentation Engineers
T2 - Lasers in Otolaryngology, Dermatology, and Tissue Welding
Y2 - 16 January 1993 through 18 January 1993
ER -