Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Paige C. Geiger; Anisha A. Gupte

doi:10.1097/JES.0b013e318201f236

Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Paige C. Geiger, Anisha A. Gupte

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

Original language	English (US)
Pages (from-to)	34-42
Number of pages	9
Journal	Exercise and Sport Sciences Reviews
Volume	39
Issue number	1
DOIs	https://doi.org/10.1097/JES.0b013e318201f236
State	Published - Jan 2011

Keywords

aging
glucose uptake
insulin signaling
mitochondria
obesity
oxidative stress
stress kinases

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1097/JES.0b013e318201f236

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abstract = "Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.",

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AB - Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

KW - aging

KW - glucose uptake

KW - insulin signaling

KW - mitochondria

KW - obesity

KW - oxidative stress

KW - stress kinases

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Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Abstract

Keywords

ASJC Scopus subject areas

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