TY - JOUR
T1 - Hepatitis B virus genotypes in southwest Iran
T2 - Molecular, serological and clinical outcomes
AU - Mojiri, Anahita
AU - Behzad-Behbahani, Abbas
AU - Saberifirozi, Mehdei
AU - Ardabili, Maryam
AU - Beheshti, Mahmood
AU - Rahsaz, Marjan
AU - Banihashemi, Mehrdad
AU - Azarpira, Negar
AU - Geramizadeh, Bita
AU - Khadang, Baharak
AU - Moaddeb, Afsaneh
AU - Ghaedi, Mojgan
AU - Heidari, Tahereh
AU - Torab, Ardeshir
AU - Salah, Alireza
AU - Amirzadeh, Saeid
AU - Jowkar, Zahra
AU - Mehrabani, Davood
AU - Amini-Bavil-Olyaee, Samad
AU - Dehyadegari, Mohammad Ali
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2008/3/14
Y1 - 2008/3/14
N2 - Aim: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. Methods: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. Results: Genotype D was the only type of HBV found in different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV-infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and-negative individuals (P = 0.24). Conclusion: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.
AB - Aim: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. Methods: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. Results: Genotype D was the only type of HBV found in different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV-infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and-negative individuals (P = 0.24). Conclusion: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.
KW - Anti-HBe
KW - Cirrhosis
KW - Hepatitis B virus-D
KW - Iran
KW - Polymerase chain reaction
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U2 - 10.3748/wjg.14.1510
DO - 10.3748/wjg.14.1510
M3 - Article
C2 - 18330939
AN - SCOPUS:41549088349
SN - 1007-9327
VL - 14
SP - 1510
EP - 1513
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 10
ER -