Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature

Amna Ahmed; Alejandro Granillo; Ethan Burns; Kerri Glassner; Nishath Naseem; Christopher Force; Suzanne M. Crumley; Ashley Drews

doi:10.1155/2020/8613840

Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature

Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M. Crumley, Ashley Drews

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.

Original language	English (US)
Article number	8613840
Journal	Case Reports in Medicine
Volume	2020
DOIs	https://doi.org/10.1155/2020/8613840
State	Published - 2020

ASJC Scopus subject areas

Medicine(all)

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title = "Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature",

abstract = "Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.",

author = "Amna Ahmed and Alejandro Granillo and Ethan Burns and Kerri Glassner and Nishath Naseem and Christopher Force and Crumley, {Suzanne M.} and Ashley Drews",

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T2 - A Case Report and Review of the Literature

AU - Ahmed, Amna

AU - Granillo, Alejandro

AU - Burns, Ethan

AU - Glassner, Kerri

AU - Naseem, Nishath

AU - Force, Christopher

AU - Crumley, Suzanne M.

AU - Drews, Ashley

PY - 2020

Y1 - 2020

N2 - Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.

AB - Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.

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Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature

Abstract

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