Histiocytic Medullary Reticulosis: The Role of Phagocytosis in Pancytopenia

Ethan Natelson; Edward C. Lynch; Robert A. Hettig; Clarence P. Alfrey

doi:10.1001/archinte.1968.00300080031007

Histiocytic Medullary Reticulosis: The Role of Phagocytosis in Pancytopenia

Ethan Natelson, Edward C. Lynch, Robert A. Hettig, Clarence P. Alfrey

Research output: Contribution to journal › Article › peer-review

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Abstract

Three patients presented with histiocytic medullary reticulosis. A review of 49 additional patients allowed an evaluation of the hematological aspects of this disease. Hemolytic anemia, granulocytopenia, and thrombocytopenia commonly observed in this disorder may result from excessive phagocytosis of blood cells by abnormal histiocytes within medullary centers of bone and lymphoid tissue. In addition, these histiocytes may serve as a repository for sequestered erythrocytic iron and cholesterol.

Original language	English (US)
Pages (from-to)	223-229
Number of pages	7
Journal	Archives of Internal Medicine
Volume	122
Issue number	3
DOIs	https://doi.org/10.1001/archinte.1968.00300080031007
State	Published - Sep 1968

ASJC Scopus subject areas

Internal Medicine

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abstract = "Three patients presented with histiocytic medullary reticulosis. A review of 49 additional patients allowed an evaluation of the hematological aspects of this disease. Hemolytic anemia, granulocytopenia, and thrombocytopenia commonly observed in this disorder may result from excessive phagocytosis of blood cells by abnormal histiocytes within medullary centers of bone and lymphoid tissue. In addition, these histiocytes may serve as a repository for sequestered erythrocytic iron and cholesterol.",

author = "Ethan Natelson and Lynch, {Edward C.} and Hettig, {Robert A.} and Alfrey, {Clarence P.}",

year = "1968",

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AU - Alfrey, Clarence P.

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AB - Three patients presented with histiocytic medullary reticulosis. A review of 49 additional patients allowed an evaluation of the hematological aspects of this disease. Hemolytic anemia, granulocytopenia, and thrombocytopenia commonly observed in this disorder may result from excessive phagocytosis of blood cells by abnormal histiocytes within medullary centers of bone and lymphoid tissue. In addition, these histiocytes may serve as a repository for sequestered erythrocytic iron and cholesterol.

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Histiocytic Medullary Reticulosis: The Role of Phagocytosis in Pancytopenia

Abstract

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