TY - JOUR
T1 - HIV-TB Coinfection among 57 Million Pregnant Women, Obstetric Complications, Alcohol Use, Drug Abuse, and Depression
AU - Fernandez, Dorian
AU - Salami, Imoleayo
AU - Davis, Janelle
AU - Mbah, Florence
AU - Kazeem, Aisha
AU - Ash, Abreah
AU - Babino, Justin
AU - Carter, Laquiesha
AU - Salemi, Jason L.
AU - Spooner, Kiara K.
AU - Olaleye, Omonike
AU - Salihu, Hamisu M.
N1 - Funding Information:
Research funding support was provided by the US Department of Health and Human Services, Health Resources and Services Administration for the Maternal and Child Health Pipeline Training Program: TSU-BCM Maternal and Child Health Student Training for Academic Readiness and Success (MCH STARS) Undergraduate Fellowship Program, Grant no. T16MC29831.
Publisher Copyright:
© 2018 Dorian Fernandez et al.
PY - 2018
Y1 - 2018
N2 - Objective. HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinfection among pregnant mothers and obstetric complications, alcohol use, drug abuse, and depression. Method. We examined inpatient hospital discharges in the United States from January 1, 2002, through December 31, 2014. We employed multivariable survey logistic regression to generate adjusted estimates for the association between infection status and study outcomes. Results. We analyzed approximately 57 million records of pregnant women and their delivery information. HIV-TB coinfection was associated with the highest risks for several obstetric complications, alcohol use, and drug abuse. The risk for alcohol abuse was more than twice as high among HIV-monoinfected as compared to TB-monoinfected mothers. That risk gap more than doubled with HIV-TB coinfection. Both HIV-monoinfected and HIV-TB coinfected mothers experienced similarly increased risks for depression. Conclusions. Mothers with HIV-TB coinfection experienced relatively heightened risks for obstetric complications, alcohol use, and drug abuse. The findings of this study underscore the importance of augmenting and enhancing social and structural support systems for HIV-TB coinfected pregnant women.
AB - Objective. HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinfection among pregnant mothers and obstetric complications, alcohol use, drug abuse, and depression. Method. We examined inpatient hospital discharges in the United States from January 1, 2002, through December 31, 2014. We employed multivariable survey logistic regression to generate adjusted estimates for the association between infection status and study outcomes. Results. We analyzed approximately 57 million records of pregnant women and their delivery information. HIV-TB coinfection was associated with the highest risks for several obstetric complications, alcohol use, and drug abuse. The risk for alcohol abuse was more than twice as high among HIV-monoinfected as compared to TB-monoinfected mothers. That risk gap more than doubled with HIV-TB coinfection. Both HIV-monoinfected and HIV-TB coinfected mothers experienced similarly increased risks for depression. Conclusions. Mothers with HIV-TB coinfection experienced relatively heightened risks for obstetric complications, alcohol use, and drug abuse. The findings of this study underscore the importance of augmenting and enhancing social and structural support systems for HIV-TB coinfected pregnant women.
KW - Adolescent
KW - Adult
KW - Age Distribution
KW - Coinfection/epidemiology
KW - Cross-Sectional Studies
KW - Female
KW - HIV Infections/epidemiology
KW - Humans
KW - Middle Aged
KW - Population Surveillance
KW - Pregnancy
KW - Pregnancy Complications, Infectious/epidemiology
KW - Socioeconomic Factors
KW - Tuberculosis/epidemiology
KW - United States/epidemiology
KW - Young Adult
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U2 - 10.1155/2018/5896901
DO - 10.1155/2018/5896901
M3 - Article
C2 - 29507814
AN - SCOPUS:85045956751
SN - 2090-2727
VL - 2018
SP - 5896901
JO - Journal of Pregnancy
JF - Journal of Pregnancy
M1 - 5896901
ER -