@inbook{7c6688314a2e46e7a91f1b67211bc81c,
title = "Hospital-Based RNA Therapeutics",
abstract = "Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical-grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology are increasing the scope of mRNA clinical applications.",
keywords = "Circular mRNA, Hospital-based mRNA therapeutics, Messenger RNA, RNA-based CAR T cell, RNA-based gene-editing tools, Self-amplifying mRNA",
author = "Damase, {Tulsi Ram} and Roman Sukhovershin and Min Zhang and Kiss, {Daniel L.} and Cooke, {John P.}",
note = "Funding Information: Acknowledgements This work was supported in part by funding from the George J. and Angelina P. Kostas Charitable Foundation, and grants to JPC from the National Institutes of Health (NIH R01 HL133254; R01 HL148338 and R01 HL157790); and from the Cancer Prevention and Research Institute of Texas (CPRIT RP200619). DLK and MZ were supported by NIH R35 GM137819 to DLK. Our gratitude to Rachael Whitehead for generating Figs. 1 and 2. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-031-08415-7_4",
language = "English (US)",
series = "RNA Technologies",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "73--92",
booktitle = "RNA Technologies",
address = "Germany",
}