Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

Errol L.G. Samuel; My Linh T. Duong; Brittany R. Bitner; Daniela C. Marcano; James M. Tour; Thomas A. Kent

doi:10.1016/j.tibtech.2014.08.005

Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

Errol L.G. Samuel, My Linh T. Duong, Brittany R. Bitner, Daniela C. Marcano, James M. Tour, Thomas A. Kent

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O₂^•-) and the hydroxyl (HO^•) radical, show no reactivity toward the nitric oxide radical (NO^•), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies.

Original language	English (US)
Pages (from-to)	501-505
Number of pages	5
Journal	Trends in Biotechnology
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/j.tibtech.2014.08.005
State	Published - Oct 1 2014

Keywords

Antioxidant
Carbon nanoparticle
Oxidative stress
Traumatic brain injury

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2014.08.005

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title = "Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants",

abstract = "Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O2•-) and the hydroxyl (HO•) radical, show no reactivity toward the nitric oxide radical (NO•), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies.",

keywords = "Antioxidant, Carbon nanoparticle, Oxidative stress, Traumatic brain injury",

author = "Samuel, {Errol L.G.} and Duong, {My Linh T.} and Bitner, {Brittany R.} and Marcano, {Daniela C.} and Tour, {James M.} and Kent, {Thomas A.}",

note = "Funding Information: This work was funded by the Mission Connect Mild Traumatic Brain Injury Consortium (W81XWH-08-2-0141, W81XWH-08-2-0143; T.A.K., J.M.T.), the Alliance for NanoHealth (W81XWH-09-02-0139; JMT), and the National Institutes of Health (NS084290-01A1; T.A.K., J.M.T.). Publisher Copyright: {\textcopyright} 2014.",

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AU - Samuel, Errol L.G.

AU - Duong, My Linh T.

AU - Bitner, Brittany R.

AU - Marcano, Daniela C.

AU - Tour, James M.

AU - Kent, Thomas A.

N1 - Funding Information: This work was funded by the Mission Connect Mild Traumatic Brain Injury Consortium (W81XWH-08-2-0141, W81XWH-08-2-0143; T.A.K., J.M.T.), the Alliance for NanoHealth (W81XWH-09-02-0139; JMT), and the National Institutes of Health (NS084290-01A1; T.A.K., J.M.T.). Publisher Copyright: © 2014.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O2•-) and the hydroxyl (HO•) radical, show no reactivity toward the nitric oxide radical (NO•), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies.

AB - Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O2•-) and the hydroxyl (HO•) radical, show no reactivity toward the nitric oxide radical (NO•), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies.

KW - Antioxidant

KW - Carbon nanoparticle

KW - Oxidative stress

KW - Traumatic brain injury

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Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

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Keywords

ASJC Scopus subject areas

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