Hyposmia: A possible biomarker of Parkinson's disease

Qian Xiao; Sheng Chen; Weidong Le

doi:10.1007/s12264-013-1390-3

Hyposmia: A possible biomarker of Parkinson's disease

Qian Xiao, Sheng Chen, Weidong Le

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in ∼90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

Original language	English (US)
Pages (from-to)	134-140
Number of pages	7
Journal	Neuroscience Bulletin
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/s12264-013-1390-3
State	Published - Feb 2014

Keywords

biomarker
hyposmia
olfaction
Parkinson's disease

ASJC Scopus subject areas

Physiology
Neuroscience(all)

Access to Document

10.1007/s12264-013-1390-3

Cite this

@article{fc0e4d3e4e8341d487daa08acae3677e,

title = "Hyposmia: A possible biomarker of Parkinson's disease",

abstract = "Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in ∼90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.",

keywords = "biomarker, hyposmia, olfaction, Parkinson's disease",

author = "Qian Xiao and Sheng Chen and Weidong Le",

note = "Funding Information: This review was supported by grants from the National Natural Science Foundation of China (81370470 and 81171201) and National Basic Research Development Program of China (2011CB510003). We thank Travis Bauer, a graduate from Rice University, for collection of reviewing materials.",

year = "2014",

month = feb,

doi = "10.1007/s12264-013-1390-3",

language = "English (US)",

volume = "30",

pages = "134--140",

journal = "Neuroscience Bulletin",

issn = "1673-7067",

publisher = "Science Press",

number = "1",

}

TY - JOUR

T1 - Hyposmia

T2 - A possible biomarker of Parkinson's disease

AU - Xiao, Qian

AU - Chen, Sheng

AU - Le, Weidong

N1 - Funding Information: This review was supported by grants from the National Natural Science Foundation of China (81370470 and 81171201) and National Basic Research Development Program of China (2011CB510003). We thank Travis Bauer, a graduate from Rice University, for collection of reviewing materials.

PY - 2014/2

Y1 - 2014/2

N2 - Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in ∼90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

AB - Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in ∼90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

KW - biomarker

KW - hyposmia

KW - olfaction

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=84895780900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895780900&partnerID=8YFLogxK

U2 - 10.1007/s12264-013-1390-3

DO - 10.1007/s12264-013-1390-3

M3 - Review article

C2 - 24136244

AN - SCOPUS:84895780900

SN - 1673-7067

VL - 30

SP - 134

EP - 140

JO - Neuroscience Bulletin

JF - Neuroscience Bulletin

IS - 1

ER -

Hyposmia: A possible biomarker of Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this