ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities

Radhika Nair; Wee Siang Teo; Vivek Mittal; Alexander Swarbrick

doi:10.1038/mt.2014.83

ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities

Radhika Nair, Wee Siang Teo, Vivek Mittal, Alexander Swarbrick

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.

Original language	English (US)
Pages (from-to)	1407-1415
Number of pages	9
Journal	Molecular Therapy
Volume	22
Issue number	8
DOIs	https://doi.org/10.1038/mt.2014.83
State	Published - Aug 2014

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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10.1038/mt.2014.83

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title = "ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities",

abstract = "The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.",

author = "Radhika Nair and Teo, {Wee Siang} and Vivek Mittal and Alexander Swarbrick",

note = "Funding Information: The authors thank Kim Moran-Jones and Mohammed Bensellam for critical reading of this manuscript. We would like to acknowledge funding from Cancer Council New South Wales, International Postgraduate Research Scholarship and Beth Yarrow Award (W.S.T.), National Health and Medical Research Council of Australia (NHMRC) and Colin Biggers & Paisley, Sydney (A.S.), and NIH grant R01-CA107429 (V.M.). A.S. is a Career Development Fellow of the NHMRC. Kate Patterson (Medipics and Prose) prepared the figures. The authors declare no conflict of interest.",

year = "2014",

month = aug,

doi = "10.1038/mt.2014.83",

language = "English (US)",

volume = "22",

pages = "1407--1415",

journal = "Molecular Therapy",

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AU - Nair, Radhika

AU - Teo, Wee Siang

AU - Mittal, Vivek

AU - Swarbrick, Alexander

N1 - Funding Information: The authors thank Kim Moran-Jones and Mohammed Bensellam for critical reading of this manuscript. We would like to acknowledge funding from Cancer Council New South Wales, International Postgraduate Research Scholarship and Beth Yarrow Award (W.S.T.), National Health and Medical Research Council of Australia (NHMRC) and Colin Biggers & Paisley, Sydney (A.S.), and NIH grant R01-CA107429 (V.M.). A.S. is a Career Development Fellow of the NHMRC. Kate Patterson (Medipics and Prose) prepared the figures. The authors declare no conflict of interest.

PY - 2014/8

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N2 - The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.

AB - The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.

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ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities

Abstract

ASJC Scopus subject areas

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