Abstract
We report a 28-year-old woman with a refractory gastric ulcer in the absence of Helicobacter pylori infection and autoimmune pancreatitis. Histologic examination of the gastric ulcer demonstrated abundant IgG4 positive plasma cells populating a lymphoplasmacytic infiltrate with associated sclerosis. Our case suggests that treatment-refractory peptic ulcer may be related to IgG4-related inflammation. When a biopsy performed to evaluate a refractory ulcer reveals abundant plasma cells and sclerotic fibrosis, an immunohistochemical stain for IgG4 and serum IgG4 measurement might be considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6588-6591 |
| Number of pages | 4 |
| Journal | International journal of clinical and experimental pathology |
| Volume | 9 |
| Issue number | 6 |
| State | Published - 2016 |
Keywords
- Gastric ulcer
- IgG4
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology