TY - JOUR
T1 - Image-derived input function for brain PET studies
T2 - Many challenges and few opportunities
AU - Zanotti-Fregonara, Paolo
AU - Chen, Kewei
AU - Liow, Jeih San
AU - Fujita, Masahiro
AU - Innis, Robert B.
PY - 2011/10
Y1 - 2011/10
N2 - Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.
AB - Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.
KW - PET
KW - derived input function
KW - kinetic modeling
KW - neuroreceptor tracers
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U2 - 10.1038/jcbfm.2011.107
DO - 10.1038/jcbfm.2011.107
M3 - Review article
C2 - 21811289
AN - SCOPUS:80053564195
SN - 0271-678X
VL - 31
SP - 1986
EP - 1998
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 10
ER -