TY - JOUR
T1 - Imaging of renal cell carcinoma in patients with acquired cystic disease of the kidney
T2 - comparison 11 C-choline and FDG PET/CT with dynamic contrast-enhanced CT
AU - Kitajima, Kazuhiro
AU - Yamamoto, Shingo
AU - Kawanaka, Yusuke
AU - Katsuura, Takayuki
AU - Fujita, Masahiro
AU - Nakanishi, Yukako
AU - Yamada, Yusuke
AU - Hashimoto, Takahiko
AU - Suzuki, Toru
AU - Go, Shuken
AU - Kanematsu, Akihiro
AU - Nojima, Michio
AU - Yamakado, Koichiro
PY - 2019/2/20
Y1 - 2019/2/20
N2 - Purpose: To evaluate renal cell carcinoma (RCC) findings in acquired cystic disease of the kidney (ACDK) shown by 11 C-choline and FDG PET/CT, and contrast-enhanced CT. Materials and methods: Six ACDK patients with 7 RCCs underwent 11 C-choline and FDG PET/CT, and contrast-enhanced CT before nephrectomy. Findings obtained with 3 imagings were evaluated and sensitivity detecting RCC was compared using 3-point grading scale (negative, equivocal, positive). The equivocal scale used for SUVmax ranged from 2.0 to 3.0 for PET/CT and a peak enhancement value ranging from 20 to 30 HU was used for CT. Result: The histopathologic subtypes of 7 RCCs were clear-cell (n = 4) and ACD-associated RCC (n = 3). The negative/equivocal/positive grading results were 0/0/7 for 11 C-choline-PET/CT, 0/3/4 for FDG-PET/CT, and 2/2/3 for CT. Three equivocal cases by FDG-PET/CT were 2 clear-cell RCCs and 1 ACD-associated RCC. CT of 3 ACD-associated RCCs showed negativity for 2 and equivocality for 1. Sensitivity defining equivocal interpretation as negative for 11 C-choline-PET/CT, FDG-PET/CT, and CT was 100% (7/7), 57.1% (4/7), and 42.9% (3/7). Conclusion: 11 C-choline-PET/CT was more sensitive to detect RCC in ACDK as compared to FDG-PET/CT and contrast-enhanced CT in our series. FDG-PET/CT may be limited for detecting clear-cell RCC, while CT may have difficulty with detection of ACD-associated RCC.
AB - Purpose: To evaluate renal cell carcinoma (RCC) findings in acquired cystic disease of the kidney (ACDK) shown by 11 C-choline and FDG PET/CT, and contrast-enhanced CT. Materials and methods: Six ACDK patients with 7 RCCs underwent 11 C-choline and FDG PET/CT, and contrast-enhanced CT before nephrectomy. Findings obtained with 3 imagings were evaluated and sensitivity detecting RCC was compared using 3-point grading scale (negative, equivocal, positive). The equivocal scale used for SUVmax ranged from 2.0 to 3.0 for PET/CT and a peak enhancement value ranging from 20 to 30 HU was used for CT. Result: The histopathologic subtypes of 7 RCCs were clear-cell (n = 4) and ACD-associated RCC (n = 3). The negative/equivocal/positive grading results were 0/0/7 for 11 C-choline-PET/CT, 0/3/4 for FDG-PET/CT, and 2/2/3 for CT. Three equivocal cases by FDG-PET/CT were 2 clear-cell RCCs and 1 ACD-associated RCC. CT of 3 ACD-associated RCCs showed negativity for 2 and equivocality for 1. Sensitivity defining equivocal interpretation as negative for 11 C-choline-PET/CT, FDG-PET/CT, and CT was 100% (7/7), 57.1% (4/7), and 42.9% (3/7). Conclusion: 11 C-choline-PET/CT was more sensitive to detect RCC in ACDK as compared to FDG-PET/CT and contrast-enhanced CT in our series. FDG-PET/CT may be limited for detecting clear-cell RCC, while CT may have difficulty with detection of ACD-associated RCC.
KW - Acquired cystic disease of the kidney (ACDK)
KW - Choline
KW - Fluorodeoxyglucose (FDG)
KW - Positron emission tomography/computed tomography (PET/CT)
KW - Renal cell carcinoma (RCC)
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U2 - 10.1007/s11604-018-0789-1
DO - 10.1007/s11604-018-0789-1
M3 - Article
C2 - 30377936
AN - SCOPUS:85055893512
SN - 1867-1071
VL - 37
SP - 165
EP - 177
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 2
ER -