Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain

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27 Scopus citations

Abstract

The integration of transcriptomic and neuroimaging data, “imaging transcriptomics,” has recently emerged to generate hypotheses about potential biological pathways underlying regional variability in neuroimaging features. However, the validity of this approach is yet to be examined in depth. Here, we sought to bridge this gap by performing transcriptomic decoding of the regional distribution of well-known molecular markers spanning different elements of the biology of the healthy human brain. Imaging transcriptomics identifies biological and cell pathways that are consistent with the known biology of a wide range of molecular neuroimaging markers. The extent to which it can capture patterns of gene expression that align well with elements of the biology of the neuroinflammatory axis, at least in healthy controls without a proinflammatory challenge, is inconclusive. Imaging transcriptomics might constitute an interesting approach to improve our understanding of the biological pathways underlying regional variability in a wide range of neuroimaging phenotypes.

Original languageEnglish (US)
Article number110173
JournalCell Reports
Volume37
Issue number13
DOIs
StatePublished - Dec 28 2021

Keywords

  • Allen Brain Atlas
  • imaging transcriptomics
  • neuroimaging
  • positron tomography emission
  • transcriptomics

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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