Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes)

James D. Triplett; Katherine A. Buzzard; Michal Lubomski; D. Sean Riminton; Michael H. Barnett; Miriam S. Welgampola; G. Michael Halmagyi; Maianh Nguyen; Klara Landau; Andrew G. Lee; Gordon T. Plant; Clare L. Fraser; Stephen W. Reddel; Todd A. Hardy

doi:10.1136/jnnp-2018-319002

Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes)

James D. Triplett, Katherine A. Buzzard, Michal Lubomski, D. Sean Riminton, Michael H. Barnett, Miriam S. Welgampola, G. Michael Halmagyi, Maianh Nguyen, Klara Landau, Andrew G. Lee, Gordon T. Plant, Clare L. Fraser, Stephen W. Reddel, Todd A. Hardy

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sjögren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. We present common disease manifestations and identify key clinical and investigation features.

Original language	English (US)
Journal	Journal of Neurology, Neurosurgery and Psychiatry
DOIs	https://doi.org/10.1136/jnnp-2018-319002
State	Published - Jan 1 2019

Keywords

Behcet
Cogan
Sjögren
Susac
Vogt koyanagi harada

ASJC Scopus subject areas

Surgery
Clinical Neurology
Psychiatry and Mental health

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Triplett, J. D., Buzzard, K. A., Lubomski, M., Riminton, D. S., Barnett, M. H., Welgampola, M. S., Halmagyi, G. M., Nguyen, M., Landau, K., Lee, A. G., Plant, G. T., Fraser, C. L., Reddel, S. W., & Hardy, T. A. (2019). Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes). Journal of Neurology, Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2018-319002

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abstract = "The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sj{\"o}gren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. We present common disease manifestations and identify key clinical and investigation features.",

keywords = "Behcet, Cogan, Sj{\"o}gren, Susac, Vogt koyanagi harada",

author = "Triplett, {James D.} and Buzzard, {Katherine A.} and Michal Lubomski and Riminton, {D. Sean} and Barnett, {Michael H.} and Welgampola, {Miriam S.} and Halmagyi, {G. Michael} and Maianh Nguyen and Klara Landau and Lee, {Andrew G.} and Plant, {Gordon T.} and Fraser, {Clare L.} and Reddel, {Stephen W.} and Hardy, {Todd A.}",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",

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AU - Triplett, James D.

AU - Buzzard, Katherine A.

AU - Lubomski, Michal

AU - Riminton, D. Sean

AU - Barnett, Michael H.

AU - Welgampola, Miriam S.

AU - Halmagyi, G. Michael

AU - Nguyen, Maianh

AU - Landau, Klara

AU - Lee, Andrew G.

AU - Plant, Gordon T.

AU - Fraser, Clare L.

AU - Reddel, Stephen W.

AU - Hardy, Todd A.

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AB - The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sjögren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. We present common disease manifestations and identify key clinical and investigation features.

KW - Behcet

KW - Cogan

KW - Sjögren

KW - Susac

KW - Vogt koyanagi harada

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Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes)

Abstract

Keywords

ASJC Scopus subject areas

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