Abstract
Heterologous boost regimens are being increasingly considered against SARS-CoV-2. We report results for the 32 of 45 participants in the Phase 1 CoV2-001 clinical trial (Kim et al., Int J Iinfect Dis 2023, 128:112–120) who elected to receive an EUA-approved SARS-CoV-2 mRNA vaccine 6 to 8 months following a two-dose primary vaccination with the GLS-5310 bi-cistronic DNA vaccine given intradermally and followed by application of suction using the GeneDerm device. Receipt of EUA-approved mRNA vaccines after GLS-5310 vaccination was well-tolerated, with no reported adverse events. Immune responses were enhanced such that binding antibody titers, neutralizing antibody titers, and T-cell responses increased 1,187-fold, 110-fold, and 2.9-fold, respectively. This paper is the first description of the immune responses following heterologous vaccination with a DNA primary series and mRNA boost.
Original language | English (US) |
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Pages (from-to) | 4206-4211 |
Number of pages | 6 |
Journal | Vaccine |
Volume | 41 |
Issue number | 29 |
DOIs | |
State | Published - Jun 29 2023 |
Keywords
- Humans
- Antibodies, Neutralizing
- Antibodies, Viral
- COVID-19/prevention & control
- COVID-19 Vaccines
- DNA
- SARS-CoV-2
- Vaccination
- Vaccines, DNA
ASJC Scopus subject areas
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
- Molecular Medicine
- Immunology and Microbiology(all)