Abstract
Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy.
Original language | English (US) |
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Pages (from-to) | 73-79 |
Number of pages | 7 |
Journal | Seminars in Cancer Biology |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2006 |
Keywords
- Antigen specificity
- Immune suppression
- Immunotherapy
- Regulatory T cells
- Toll-like receptors
- Treg cells
ASJC Scopus subject areas
- Cancer Research