TY - JOUR
T1 - Immunohistochemical demonstration of the endothelial nature of aortic intimal sarcoma
AU - Haber, L. M.
AU - Truong, Luan
PY - 1988
Y1 - 1988
N2 - Primary sarcomas of the aorta are rare; fewer than 30 cases have been reported. Among these, the majority are intraluminal and apparently intimal in origin. Extensive histochemical and electron-microscopic evaluation of these tumors has not previously been performed. We present a case of aortic intimal sarcoma in a 70-year-old man whose resected aorta showed multifocal, intimal tumor that appeared on light microscopy to be undifferentiated sarcoma. Electron microscopy was not helpful; however, immunohistochemical studies confirmed the endothelial nature of this neoplasm. The multifocal pattern of the tumor and the presence of intervening, atypical, proliferative endothelial cells suggests that endothelial dysplasia may have been a precursor lesion.
AB - Primary sarcomas of the aorta are rare; fewer than 30 cases have been reported. Among these, the majority are intraluminal and apparently intimal in origin. Extensive histochemical and electron-microscopic evaluation of these tumors has not previously been performed. We present a case of aortic intimal sarcoma in a 70-year-old man whose resected aorta showed multifocal, intimal tumor that appeared on light microscopy to be undifferentiated sarcoma. Electron microscopy was not helpful; however, immunohistochemical studies confirmed the endothelial nature of this neoplasm. The multifocal pattern of the tumor and the presence of intervening, atypical, proliferative endothelial cells suggests that endothelial dysplasia may have been a precursor lesion.
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U2 - 10.1097/00000478-198810000-00010
DO - 10.1097/00000478-198810000-00010
M3 - Article
C2 - 3138923
AN - SCOPUS:0023695283
SN - 0147-5185
VL - 12
SP - 798
EP - 802
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 10
ER -