Immunosuppression for Multiple Sclerosis

Kenneth H. Fischbeck; Aaron E. Miller; V. Utermohlen; M. Berkowitz; David P. Huston; Marjorie J. White; Robert B. Bressler; Victor M. Rivera; Benjamin Cooper; James M. Killian; Stephen L. Hauser; David M. Dawson; Howard L. Weiner; James R. Lehrich; M. Flint Beal; John A. Mills; Sherwin V. Kevy; Richard D. Propper

doi:10.1056/NEJM198307283090411

Immunosuppression for Multiple Sclerosis

Kenneth H. Fischbeck, Aaron E. Miller, V. Utermohlen, M. Berkowitz, David P. Huston, Marjorie J. White, Robert B. Bressler, Victor M. Rivera, Benjamin Cooper, James M. Killian, Stephen L. Hauser, David M. Dawson, Howard L. Weiner, James R. Lehrich, M. Flint Beal, John A. Mills, Sherwin V. Kevy, Richard D. Propper

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: The study of the efficacy of cyclophosphamide in the treatment of multiple sclerosis (Jan. 27 issue)* has four major flaws. First of all, the assessment of the response to therapy was based on subjective impressions of the patients and investigators, who were aware of the type of treatment received. Both groups of observers would be expected to have a vested interest in the success of the experimental protocol, which would bias their reporting. This failure to use an accepted double-blind technique needs a better explanation. Even complete scalp alopecia could be masked, so that an unbiased observer.

Original language	English (US)
Pages (from-to)	239-241
Number of pages	3
Journal	New England Journal of Medicine
Volume	309
Issue number	4
DOIs	https://doi.org/10.1056/NEJM198307283090411
State	Published - Jul 28 1983

ASJC Scopus subject areas

Medicine(all)

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Fischbeck, K. H., Miller, A. E., Utermohlen, V., Berkowitz, M., Huston, D. P., White, M. J., Bressler, R. B., Rivera, V. M., Cooper, B., Killian, J. M., Hauser, S. L., Dawson, D. M., Weiner, H. L., Lehrich, J. R., Beal, M. F., Mills, J. A., Kevy, S. V., & Propper, R. D. (1983). Immunosuppression for Multiple Sclerosis. New England Journal of Medicine, 309(4), 239-241. https://doi.org/10.1056/NEJM198307283090411

Fischbeck, KH, Miller, AE, Utermohlen, V, Berkowitz, M, Huston, DP, White, MJ, Bressler, RB, Rivera, VM, Cooper, B, Killian, JM, Hauser, SL, Dawson, DM, Weiner, HL, Lehrich, JR, Beal, MF, Mills, JA, Kevy, SV & Propper, RD 1983, 'Immunosuppression for Multiple Sclerosis', New England Journal of Medicine, vol. 309, no. 4, pp. 239-241. https://doi.org/10.1056/NEJM198307283090411

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title = "Immunosuppression for Multiple Sclerosis",

abstract = "To the Editor: The study of the efficacy of cyclophosphamide in the treatment of multiple sclerosis (Jan. 27 issue)* has four major flaws. First of all, the assessment of the response to therapy was based on subjective impressions of the patients and investigators, who were aware of the type of treatment received. Both groups of observers would be expected to have a vested interest in the success of the experimental protocol, which would bias their reporting. This failure to use an accepted double-blind technique needs a better explanation. Even complete scalp alopecia could be masked, so that an unbiased observer.",

author = "Fischbeck, {Kenneth H.} and Miller, {Aaron E.} and V. Utermohlen and M. Berkowitz and Huston, {David P.} and White, {Marjorie J.} and Bressler, {Robert B.} and Rivera, {Victor M.} and Benjamin Cooper and Killian, {James M.} and Hauser, {Stephen L.} and Dawson, {David M.} and Weiner, {Howard L.} and Lehrich, {James R.} and Beal, {M. Flint} and Mills, {John A.} and Kevy, {Sherwin V.} and Propper, {Richard D.}",

year = "1983",

month = jul,

day = "28",

doi = "10.1056/NEJM198307283090411",

language = "English (US)",

volume = "309",

pages = "239--241",

journal = "New England Journal of Medicine",

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T1 - Immunosuppression for Multiple Sclerosis

AU - Fischbeck, Kenneth H.

AU - Miller, Aaron E.

AU - Utermohlen, V.

AU - Berkowitz, M.

AU - Huston, David P.

AU - White, Marjorie J.

AU - Bressler, Robert B.

AU - Rivera, Victor M.

AU - Cooper, Benjamin

AU - Killian, James M.

AU - Hauser, Stephen L.

AU - Dawson, David M.

AU - Weiner, Howard L.

AU - Lehrich, James R.

AU - Beal, M. Flint

AU - Mills, John A.

AU - Kevy, Sherwin V.

AU - Propper, Richard D.

PY - 1983/7/28

Y1 - 1983/7/28

N2 - To the Editor: The study of the efficacy of cyclophosphamide in the treatment of multiple sclerosis (Jan. 27 issue)* has four major flaws. First of all, the assessment of the response to therapy was based on subjective impressions of the patients and investigators, who were aware of the type of treatment received. Both groups of observers would be expected to have a vested interest in the success of the experimental protocol, which would bias their reporting. This failure to use an accepted double-blind technique needs a better explanation. Even complete scalp alopecia could be masked, so that an unbiased observer.

AB - To the Editor: The study of the efficacy of cyclophosphamide in the treatment of multiple sclerosis (Jan. 27 issue)* has four major flaws. First of all, the assessment of the response to therapy was based on subjective impressions of the patients and investigators, who were aware of the type of treatment received. Both groups of observers would be expected to have a vested interest in the success of the experimental protocol, which would bias their reporting. This failure to use an accepted double-blind technique needs a better explanation. Even complete scalp alopecia could be masked, so that an unbiased observer.

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JO - New England Journal of Medicine

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ER -

Immunosuppression for Multiple Sclerosis

Abstract

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