Abstract
Biological applications of porous silicon (PSi) include, but are not limited to, delivery of drugs, imaging, and immune modulatory agents. Porous particles in defined sizes and shapes can be made from silicon wafers using a combination of photolithography and electrochemical etching. The resulting particles are biocompatible, degrade into nontoxic products, and are easily functionalized and loaded with cargo.With respect to immunotherapy applications, particles are functionalized with ligands, specifically pathogen-associated molecular patterns, that enable them to work with the immune system, activating antigen-presenting cells (APC) to initiate immune responses against foreign invaders and pathogenic cells.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Porous Silicon |
| Subtitle of host publication | Second Edition |
| Publisher | Springer International Publishing |
| Pages | 1419-1432 |
| Number of pages | 14 |
| Volume | 2-2 |
| ISBN (Electronic) | 9783319713816 |
| ISBN (Print) | 9783319713793 |
| DOIs | |
| State | Published - Jul 4 2018 |
Keywords
- Adaptive immunity
- Adjuvant
- Antibody
- Antigen
- Cellular immunity
- Cross presentation of antigen
- Cytokine
- Dendritic cells
- Macrophages
- Mimetics
- Myeloid cells
- Pathogen-associated molecular patterns
- T cells
- Toll-like receptor
ASJC Scopus subject areas
- Engineering(all)
- Materials Science(all)
- Chemistry(all)
- Physics and Astronomy(all)
- Biochemistry, Genetics and Molecular Biology(all)