Immunotherapeutics for head and neck squamous cell carcinoma stem cells

X. Qian; F. Leonard; Y. Wenhao; H. Sudhoff; T. K. Hoffmann; S. Ferrone; A. M. Kaufmann; A. E. Albers

doi:10.1007/s00106-020-00819-y

Immunotherapeutics for head and neck squamous cell carcinoma stem cells

X. Qian, F. Leonard, Y. Wenhao, H. Sudhoff, T. K. Hoffmann, S. Ferrone, A. M. Kaufmann, A. E. Albers

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.

Original language	English (US)
Pages (from-to)	94-99
Number of pages	6
Journal	HNO
Volume	68
Issue number	2
DOIs	https://doi.org/10.1007/s00106-020-00819-y
State	Published - Feb 1 2020

Keywords

Cancer nanomedicine
Cancer stem cell
Cancer vaccine
Immunotherapy
Nanotechnology
Humans
Cell Line, Tumor
Neoplastic Stem Cells
Head and Neck Neoplasms/therapy
Squamous Cell Carcinoma of Head and Neck/therapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1007/s00106-020-00819-y

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title = "Immunotherapeutics for head and neck squamous cell carcinoma stem cells",

abstract = "Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.",

keywords = "Cancer nanomedicine, Cancer stem cell, Cancer vaccine, Immunotherapy, Nanotechnology, Humans, Cell Line, Tumor, Neoplastic Stem Cells, Head and Neck Neoplasms/therapy, Squamous Cell Carcinoma of Head and Neck/therapy",

author = "X. Qian and F. Leonard and Y. Wenhao and H. Sudhoff and Hoffmann, {T. K.} and S. Ferrone and Kaufmann, {A. M.} and Albers, {A. E.}",

note = "Funding Information: This work was partially supported by the Medical and the Health Science Project of Zhejiang Province (2019KY327) and the National Natural Science Foundation of China (81702091) and Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital. Publisher Copyright: {\textcopyright} 2020, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.",

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doi = "10.1007/s00106-020-00819-y",

language = "English (US)",

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T1 - Immunotherapeutics for head and neck squamous cell carcinoma stem cells

AU - Qian, X.

AU - Leonard, F.

AU - Wenhao, Y.

AU - Sudhoff, H.

AU - Hoffmann, T. K.

AU - Ferrone, S.

AU - Kaufmann, A. M.

AU - Albers, A. E.

N1 - Funding Information: This work was partially supported by the Medical and the Health Science Project of Zhejiang Province (2019KY327) and the National Natural Science Foundation of China (81702091) and Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital. Publisher Copyright: © 2020, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.

AB - Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.

KW - Cancer nanomedicine

KW - Cancer stem cell

KW - Cancer vaccine

KW - Immunotherapy

KW - Nanotechnology

KW - Humans

KW - Cell Line, Tumor

KW - Neoplastic Stem Cells

KW - Head and Neck Neoplasms/therapy

KW - Squamous Cell Carcinoma of Head and Neck/therapy

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DO - 10.1007/s00106-020-00819-y

M3 - Review article

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SN - 0017-6192

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SP - 94

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JF - HNO

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Immunotherapeutics for head and neck squamous cell carcinoma stem cells

Abstract

Keywords

ASJC Scopus subject areas

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