Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis

Abigail M. Louis; Amna M. Ali; Sagar B. Patel; Kenneth C. Fan; Effie Z. Rahman; William A. Pearce; Stephanie Trejo Corona; Cecilia Villanueva Boone; Hannah J. Yu; Charles C. Wykoff

doi:10.1177/24741264231191339

Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis

Abigail M. Louis, Amna M. Ali, Sagar B. Patel, Kenneth C. Fan, Effie Z. Rahman, William A. Pearce, Stephanie Trejo Corona, Cecilia Villanueva Boone, Hannah J. Yu, Charles C. Wykoff

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicenter retina practice in Houston, Texas, from January 2015 to August 2021 were retrospectively reviewed. The primary outcome was rate of endophthalmitis after intravitreal injection. Results: A total of 307 349 injections were performed during the study period and 101 cases of endophthalmitis were identified (0.033%). PFS use was associated with a decreased risk of endophthalmitis (relative risk [RR], 0.320; 95% CI, 0.198-0.518, P <.001); 54 cases of endophthalmitis occurred in the GVP group of aflibercept and ranibizumab (0.052%) compared with 24 in the PFS group (0.017%). There was no difference in the endophthalmitis rates with or without universal masking (RR, 0.953; 95% CI 0.616-1.473, P =.91). Discussion: PFS use was associated with a significant reduction in the rate of endophthalmitis while the use of surgical face masks did not appear to significantly impact the rate of endophthalmitis.

Original language	English (US)
Pages (from-to)	382-388
Number of pages	7
Journal	Journal of VitreoRetinal Diseases
Volume	7
Issue number	5
DOIs	https://doi.org/10.1177/24741264231191339
State	Published - Sep 1 2023

Keywords

anti-VEGF
endophthalmitis
intravitreal injection
masking
prefilled syringe

ASJC Scopus subject areas

Ophthalmology

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10.1177/24741264231191339

Cite this

@article{a89edfba338d4f1ba9fb6c33df134e1e,

title = "Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis",

abstract = "Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicenter retina practice in Houston, Texas, from January 2015 to August 2021 were retrospectively reviewed. The primary outcome was rate of endophthalmitis after intravitreal injection. Results: A total of 307 349 injections were performed during the study period and 101 cases of endophthalmitis were identified (0.033%). PFS use was associated with a decreased risk of endophthalmitis (relative risk [RR], 0.320; 95% CI, 0.198-0.518, P <.001); 54 cases of endophthalmitis occurred in the GVP group of aflibercept and ranibizumab (0.052%) compared with 24 in the PFS group (0.017%). There was no difference in the endophthalmitis rates with or without universal masking (RR, 0.953; 95% CI 0.616-1.473, P =.91). Discussion: PFS use was associated with a significant reduction in the rate of endophthalmitis while the use of surgical face masks did not appear to significantly impact the rate of endophthalmitis.",

keywords = "anti-VEGF, endophthalmitis, intravitreal injection, masking, prefilled syringe",

author = "Louis, {Abigail M.} and Ali, {Amna M.} and Patel, {Sagar B.} and Fan, {Kenneth C.} and Rahman, {Effie Z.} and Pearce, {William A.} and {Trejo Corona}, Stephanie and {Villanueva Boone}, Cecilia and Yu, {Hannah J.} and Wykoff, {Charles C.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

month = sep,

day = "1",

doi = "10.1177/24741264231191339",

language = "English (US)",

volume = "7",

pages = "382--388",

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TY - JOUR

T1 - Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis

AU - Louis, Abigail M.

AU - Ali, Amna M.

AU - Patel, Sagar B.

AU - Fan, Kenneth C.

AU - Rahman, Effie Z.

AU - Pearce, William A.

AU - Trejo Corona, Stephanie

AU - Villanueva Boone, Cecilia

AU - Yu, Hannah J.

AU - Wykoff, Charles C.

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicenter retina practice in Houston, Texas, from January 2015 to August 2021 were retrospectively reviewed. The primary outcome was rate of endophthalmitis after intravitreal injection. Results: A total of 307 349 injections were performed during the study period and 101 cases of endophthalmitis were identified (0.033%). PFS use was associated with a decreased risk of endophthalmitis (relative risk [RR], 0.320; 95% CI, 0.198-0.518, P <.001); 54 cases of endophthalmitis occurred in the GVP group of aflibercept and ranibizumab (0.052%) compared with 24 in the PFS group (0.017%). There was no difference in the endophthalmitis rates with or without universal masking (RR, 0.953; 95% CI 0.616-1.473, P =.91). Discussion: PFS use was associated with a significant reduction in the rate of endophthalmitis while the use of surgical face masks did not appear to significantly impact the rate of endophthalmitis.

AB - Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicenter retina practice in Houston, Texas, from January 2015 to August 2021 were retrospectively reviewed. The primary outcome was rate of endophthalmitis after intravitreal injection. Results: A total of 307 349 injections were performed during the study period and 101 cases of endophthalmitis were identified (0.033%). PFS use was associated with a decreased risk of endophthalmitis (relative risk [RR], 0.320; 95% CI, 0.198-0.518, P <.001); 54 cases of endophthalmitis occurred in the GVP group of aflibercept and ranibizumab (0.052%) compared with 24 in the PFS group (0.017%). There was no difference in the endophthalmitis rates with or without universal masking (RR, 0.953; 95% CI 0.616-1.473, P =.91). Discussion: PFS use was associated with a significant reduction in the rate of endophthalmitis while the use of surgical face masks did not appear to significantly impact the rate of endophthalmitis.

KW - anti-VEGF

KW - endophthalmitis

KW - intravitreal injection

KW - masking

KW - prefilled syringe

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JO - Journal of VitreoRetinal Diseases

JF - Journal of VitreoRetinal Diseases

IS - 5

ER -

Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis

Abstract

Keywords

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