TY - JOUR
T1 - Implantable cardioverter-defibrillator and wait-list outcomes in pediatric patients awaiting heart transplantation
AU - El-Assaad, Iqbal
AU - Al-Kindi, Sadeer G.
AU - Oliveira, Guilherme H.
AU - Boyle, Gerard J.
AU - Aziz, Peter F.
N1 - Publisher Copyright:
© 2015 Heart Rhythm Society.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background Implantable cardioverter-defibrillators (ICDs) reduce the incidence of sudden cardiac death (SCD) in adults with end-stage heart failure; however, their efficacy in pediatric patients awaiting heart transplantation is not well established. Objectives This study sought to investigate the role of ICDs in preventing SCD and waiting list mortality as well as to determine risk factors for SCD in pediatric patients listed for heart transplantation. Methods We queried the United Network for Organ Sharing database for all pediatric patients (age ≤18 years) listed for heart transplantation (2005-2014). The Cox proportional hazards model was used to identify risk factors for SCD and all-cause mortality. Results A total of 5072 mostly White (55%) male (55%) patients (mean age 6.2 ± 6.5 years) were identified, of whom 426 (8.3%) had ICD at listing. At 6 months, 65% underwent heart transplantation, 15% died (4% died of SCD), and 20% were alive. In a multivariable model, United Network for Organ Sharing status 1B (hazard ratio [HR] 0.52; 95% confidence interval [CI] 0.29-0.95; P =.03), myocarditis (HR 0.19; 95% CI 0.05-0.77; P =.02), restrictive cardiomyopathy (HR 0.19; 95% CI 0.05-0.76; P =.02), and dilated cardiomyopathy (HR 0.32; 95% CI 0.20-0.52; P <.001) were associated with lower SCD risk, while younger age at listing (HR 0.94 per year; 95% CI 0.90-0.98; P =.003) was associated with higher SCD risk. ICD at listing was not associated with reduced SCD (P =.12), all-cause mortality, or delisting (P =.57). Conclusion In pediatric patients listed for heart transplantation, the risk of SCD remains low and does not differ between patients with and without an ICD at listing.
AB - Background Implantable cardioverter-defibrillators (ICDs) reduce the incidence of sudden cardiac death (SCD) in adults with end-stage heart failure; however, their efficacy in pediatric patients awaiting heart transplantation is not well established. Objectives This study sought to investigate the role of ICDs in preventing SCD and waiting list mortality as well as to determine risk factors for SCD in pediatric patients listed for heart transplantation. Methods We queried the United Network for Organ Sharing database for all pediatric patients (age ≤18 years) listed for heart transplantation (2005-2014). The Cox proportional hazards model was used to identify risk factors for SCD and all-cause mortality. Results A total of 5072 mostly White (55%) male (55%) patients (mean age 6.2 ± 6.5 years) were identified, of whom 426 (8.3%) had ICD at listing. At 6 months, 65% underwent heart transplantation, 15% died (4% died of SCD), and 20% were alive. In a multivariable model, United Network for Organ Sharing status 1B (hazard ratio [HR] 0.52; 95% confidence interval [CI] 0.29-0.95; P =.03), myocarditis (HR 0.19; 95% CI 0.05-0.77; P =.02), restrictive cardiomyopathy (HR 0.19; 95% CI 0.05-0.76; P =.02), and dilated cardiomyopathy (HR 0.32; 95% CI 0.20-0.52; P <.001) were associated with lower SCD risk, while younger age at listing (HR 0.94 per year; 95% CI 0.90-0.98; P =.003) was associated with higher SCD risk. ICD at listing was not associated with reduced SCD (P =.12), all-cause mortality, or delisting (P =.57). Conclusion In pediatric patients listed for heart transplantation, the risk of SCD remains low and does not differ between patients with and without an ICD at listing.
KW - Heart transplant
KW - Implantable cardioverter-defibrillator
KW - Pediatric
KW - Sudden cardiac death
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U2 - 10.1016/j.hrthm.2015.07.036
DO - 10.1016/j.hrthm.2015.07.036
M3 - Article
C2 - 26247317
AN - SCOPUS:84959866500
SN - 1547-5271
VL - 12
SP - 2443
EP - 2448
JO - Heart Rhythm
JF - Heart Rhythm
IS - 12
ER -