@article{273b7e6eef2f4bc28abc87d2d5476471,
title = "Implications of the human gut-brain and gut-cancer axes for future nanomedicine",
abstract = "Recent clinical and pathological evidence have implicated the gut microbiota as a nexus for modulating the homeostasis of the human body, impacting conditions from cancer and dementia to obesity and social behavior. The connections between microbiota and human diseases offer numerous opportunities in medicine, most of which have limited or no therapeutic solutions available. In light of this paradigm-setting trend in science, this review aims to provide a comprehensive and timely summary of the mechanistic pathways governing the gut microbiota and their implications for nanomedicines targeting cancer and neurodegenerative diseases. Specifically, we discuss in parallel the beneficial and pathogenic relationship of the gut microbiota along the gut-brain and gut-cancer axes, elaborate on the impact of dysbiosis and the gastrointestinal corona on the efficacy of nanomedicines, and highlight a molecular mimicry that manipulates the universal cross-β backbone of bacterial amyloid to accelerate neurological disorders. This review further offers a forward-looking section on the rational design of cancer and dementia nanomedicines exploiting the gut-brain and gut-cancer axes.",
keywords = "Alzheimer{\textquoteright}s disease, Amyloid, Cancer, Corona, Gut-brain axis, Gut-cancer axis, Microbiota, Nanomedicine, Parkinson{\textquoteright}s disease",
author = "Ibrahim Javed and Xuejing Cui and Xiaoyu Wang and Monika Mortimer and Nikolaos Andrikopoulos and Yuhuan Li and Davis, {Thomas P.} and Yuliang Zhao and Ke, {Pu Chun} and Chunying Chen",
note = "Funding Information: This research was supported by the Ministry of Science and Technology of China (2016YFA0201600 and 2016YFE0133100), ARC project no. CE140100036, the National Natural Science Foundation of China (31800844 and 51861145302), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505), the Research and Development Project in Key Areas of Guangdong Province (2019B090917011), the CAS Key Research Program for Frontier Sciences (QYZDJ-SSWSLH022), the Austrian-Chinese Cooperative RTD Project (GJHZ201949, FFG and CAS), and CAS interdisciplinary innovation team. Funding Information: This research was supported by the Ministry of Science and Technology of China (2016YFA0201600 and 2016YFE0133100), ARC project no. CE140100036, the National Natural Science Foundation of China (31800844 and 51861145302), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505), the Research and Development Project in Key Areas of Guangdong Province (2019B090917011), the CAS Key Research Program for Frontier Sciences (QYZDJ-SSW-SLH022), the Austrian-Chinese Cooperative RTD Project (GJHZ201949, FFG and CAS), and CAS interdisciplinary innovation team. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = nov,
day = "24",
doi = "10.1021/acsnano.0c07258",
language = "English (US)",
volume = "14",
pages = "14391--14416",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "11",
}