TY - GEN
T1 - In-vitro evaluation of sensors and amplifiers to measure left ventricular pressure in mice
AU - Hartley, Craig J.
AU - Reddy, Anilkumar K.
AU - Taffet, George
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Mice are becoming more common as research models, and several companies now manufacture sensors and instrumentation to measure left ventricular (LV) pressure and volume in mice. It is often assumed that pressure is easier to measure than volume, and that all sensors perform similarly, but there are differences. We measured in-vitro the frequency and step responses, immersion response, stability, accuracy, linearity, and sensitivity to lateral or bending force of several solid-state sensors and amplifiers commonly used in mice. We tested 4 microsensors each from Millar, Scisense, and RADI, and also fluidfilled catheters. All solid-state sensors were stable with drifts of <1 mmHg/hr, had flat frequency response to >1 kHz, and were accurate and linear to within +/-2 mmHg from 0-300 mmHg. The frequency response of the fluid-filled catheter was down by 50% at 30 Hz. The amplifiers from Millar, Scisense, and RADI, had time delays of 0.2, 3.2 and 10.6 ms respectively. The Millar and RADI sensors were unresponsive to lateral forces, but the Scisense catheters had sensitivities as high as 5.3 mmHg/g. There are significant differences in solid state pressure sensors and amplifiers which could generate offsets, time delays, and distortions which could go unrecognized in-vivo.
AB - Mice are becoming more common as research models, and several companies now manufacture sensors and instrumentation to measure left ventricular (LV) pressure and volume in mice. It is often assumed that pressure is easier to measure than volume, and that all sensors perform similarly, but there are differences. We measured in-vitro the frequency and step responses, immersion response, stability, accuracy, linearity, and sensitivity to lateral or bending force of several solid-state sensors and amplifiers commonly used in mice. We tested 4 microsensors each from Millar, Scisense, and RADI, and also fluidfilled catheters. All solid-state sensors were stable with drifts of <1 mmHg/hr, had flat frequency response to >1 kHz, and were accurate and linear to within +/-2 mmHg from 0-300 mmHg. The frequency response of the fluid-filled catheter was down by 50% at 30 Hz. The amplifiers from Millar, Scisense, and RADI, had time delays of 0.2, 3.2 and 10.6 ms respectively. The Millar and RADI sensors were unresponsive to lateral forces, but the Scisense catheters had sensitivities as high as 5.3 mmHg/g. There are significant differences in solid state pressure sensors and amplifiers which could generate offsets, time delays, and distortions which could go unrecognized in-vivo.
KW - Blood pressure
KW - Fidelity
KW - Frequency response
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U2 - 10.1109/iembs.2008.4649315
DO - 10.1109/iembs.2008.4649315
M3 - Conference contribution
C2 - 19162818
AN - SCOPUS:61849129978
SN - 9781424418152
T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
SP - 965
EP - 968
BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Y2 - 20 August 2008 through 25 August 2008
ER -