Abstract
Innate immune pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors, and AIM2-like receptors (ALRs), function as pathogen pattern recognition molecules that sensor and initiate innate and adaptive immune responses against microbes and cancer cells. Recognition of pathogen-derived ligands by PRRs expressed on many types of cells, including dendritic cells (DCs) and T cells, triggers the NF-kB, type 1 interferon and inflammasome activation pathways, leading to the production of proinflammatory cytokines that are essential in inflammation and inflammation-linked cancer. Both positive and negative regulators are critical in the maintenance of innate immune homeostasis. In this review, I focus on the current understanding of PRRs, signaling pathways and their regulation through negative regulators. Their relevance to cancer will be discussed as well.
Original language | English (US) |
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Title of host publication | Innate Immune Regulation and Cancer Immunotherapy |
Publisher | Springer New York |
Pages | 61-88 |
Number of pages | 28 |
ISBN (Print) | 9781441999146, 9781441999139 |
DOIs | |
State | Published - Jan 1 2012 |
ASJC Scopus subject areas
- Medicine(all)