Innate immunity and epigenetic plasticity in cellular reprogramming

John P. Cooke; Nazish Sayed; Jieun Lee; Wing Tak Wong

doi:10.1016/j.gde.2014.11.002

Innate immunity and epigenetic plasticity in cellular reprogramming

John P. Cooke, Nazish Sayed, Jieun Lee, Wing Tak Wong

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.

Original language	English (US)
Pages (from-to)	89-91
Number of pages	3
Journal	Current Opinion in Genetics and Development
Volume	28
DOIs	https://doi.org/10.1016/j.gde.2014.11.002
State	Published - Oct 1 2014

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2014.11.002

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title = "Innate immunity and epigenetic plasticity in cellular reprogramming",

abstract = "Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.",

author = "Cooke, {John P.} and Nazish Sayed and Jieun Lee and Wong, {Wing Tak}",

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doi = "10.1016/j.gde.2014.11.002",

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T1 - Innate immunity and epigenetic plasticity in cellular reprogramming

AU - Cooke, John P.

AU - Sayed, Nazish

AU - Lee, Jieun

AU - Wong, Wing Tak

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.

AB - Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.

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U2 - 10.1016/j.gde.2014.11.002

DO - 10.1016/j.gde.2014.11.002

M3 - Review article

C2 - 25461456

AN - SCOPUS:84912014804

SN - 0959-437X

VL - 28

SP - 89

EP - 91

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

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Innate immunity and epigenetic plasticity in cellular reprogramming

Abstract

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