TY - JOUR
T1 - Innovative Options for Bone Metastasis Treatment
T2 - An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons
AU - Guerrieri, Ania Naila
AU - Montesi, Monica
AU - Sprio, Simone
AU - Laranga, Roberta
AU - Mercatali, Laura
AU - Tampieri, Anna
AU - Donati, Davide Maria
AU - Lucarelli, Enrico
N1 - Funding Information:
This research was funded by the Italian Health Ministry 5 × 1000 fund, the project Dinamica POR FERSR 2014–2020 PG/2018/632022 and the project Biobos Ministero della Salute Progetto Finalizzata GR-2016-02364704.
Funding Information:
The authors wish to thank Dr. Federico Vacca who provided his knowledge that greatly supported the drafting/writing of this review, Mariapia Cumani (Laboratorio di Disegno Anatomico, Dip. Scienze Biomediche e Neuromotorie, Universit? di Bologna c/o Istituto Ortopedico Rizzoli ? Bologna, Italy) for Figures 1, 2 and Giovanna Danna (University of Wisconsin-Madison) for editing. Funding. This research was funded by the Italian Health Ministry 5 ? 1000 fund, the project Dinamica POR FERSR 2014?2020 PG/2018/632022 and the project Biobos Ministero della Salute Progetto Finalizzata GR-2016-02364704.
Publisher Copyright:
© Copyright © 2020 Guerrieri, Montesi, Sprio, Laranga, Mercatali, Tampieri, Donati and Lucarelli.
PY - 2020/10/6
Y1 - 2020/10/6
N2 - Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.
AB - Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.
KW - 3D scaffolds
KW - biomaterials
KW - bone metastasis
KW - bone regeneration
KW - oncology
KW - orthopedic bioimplants
KW - patents
KW - smart biomaterials
UR - http://www.scopus.com/inward/record.url?scp=85093360369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85093360369&partnerID=8YFLogxK
U2 - 10.3389/fbioe.2020.589964
DO - 10.3389/fbioe.2020.589964
M3 - Review article
C2 - 33123519
AN - SCOPUS:85093360369
SN - 2296-4185
VL - 8
SP - 589964
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
M1 - 589964
ER -