TY - GEN
T1 - Integrated prototype for point-of-care diagnosis of chlamydia trachomatis infections
AU - Sathish, Shivani
AU - Toda-Peters, Kazumi
AU - Shen, Amy Q.
PY - 2019
Y1 - 2019
N2 - Clinical research has shown that bacterial Chlamydia trachomatis infections are the most prevalent sexually transmitted infections, contributing to high rates of miscarriages and infertility worldwide. These infections are conventionally diagnosed via laboratory-based serological tests that quantify C.trachomatis-specific antibodies from patient blood. [1] These expensive and time-consuming tests are being replaced by “at home” testing kits that allow the patients to obtain the diagnosis without repetitive clinical visits. However, these kits heavily rely on the precision of the user to perform the procedures, leading to increased variability in diagnostic results. Here, we developed an integrated palm-sized antibody-testing prototype consisting of a Fluid Handling Device (FHD), that allows precise sample mixing, filtration and delivery of the processed fluids to an on-board microfluidic assay device for detection of C.trachomatis-specific antibodies, within an enclosed, manually-operated system, while decreasing contamination and enabling rapid and replicable antibody detection.
AB - Clinical research has shown that bacterial Chlamydia trachomatis infections are the most prevalent sexually transmitted infections, contributing to high rates of miscarriages and infertility worldwide. These infections are conventionally diagnosed via laboratory-based serological tests that quantify C.trachomatis-specific antibodies from patient blood. [1] These expensive and time-consuming tests are being replaced by “at home” testing kits that allow the patients to obtain the diagnosis without repetitive clinical visits. However, these kits heavily rely on the precision of the user to perform the procedures, leading to increased variability in diagnostic results. Here, we developed an integrated palm-sized antibody-testing prototype consisting of a Fluid Handling Device (FHD), that allows precise sample mixing, filtration and delivery of the processed fluids to an on-board microfluidic assay device for detection of C.trachomatis-specific antibodies, within an enclosed, manually-operated system, while decreasing contamination and enabling rapid and replicable antibody detection.
KW - At-home tests
KW - Fluid handling device
KW - Microfluidic immunoassay
KW - Sexually transmitted infections
UR - http://www.scopus.com/inward/record.url?scp=85094946798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094946798&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094946798
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 1580
EP - 1581
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -