Intra-arterial delivery of cell therapies for stroke

Vivek Misra; Aditya Lal; Ramy El Khoury; Peng R. Chen; Sean I. Savitz

doi:10.1089/scd.2011.0612

Intra-arterial delivery of cell therapies for stroke

Vivek Misra, Aditya Lal, Ramy El Khoury, Peng R. Chen, Sean I. Savitz

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Cell therapy is a novel investigational approach to enhance stroke recovery. Intra-arterial (IA) delivery has the potential advantage of selectively targeting cell therapies to the ischemic brain tissue. Over the past 10 years, IA cell delivery has been under investigation in patients with cardiac and peripheral vascular disease, and these studies have reported promising results. This article reviews the trial methodology and procedural details of these studies and discusses the rationale and challenges in designing IA cell therapy trials for ischemic stroke.

Original language	English (US)
Pages (from-to)	1007-1015
Number of pages	9
Journal	Stem Cells and Development
Volume	21
Issue number	7
DOIs	https://doi.org/10.1089/scd.2011.0612
State	Published - May 1 2012

ASJC Scopus subject areas

Hematology
Developmental Biology
Cell Biology

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10.1089/scd.2011.0612

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title = "Intra-arterial delivery of cell therapies for stroke",

abstract = "Cell therapy is a novel investigational approach to enhance stroke recovery. Intra-arterial (IA) delivery has the potential advantage of selectively targeting cell therapies to the ischemic brain tissue. Over the past 10 years, IA cell delivery has been under investigation in patients with cardiac and peripheral vascular disease, and these studies have reported promising results. This article reviews the trial methodology and procedural details of these studies and discusses the rationale and challenges in designing IA cell therapy trials for ischemic stroke.",

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AU - Misra, Vivek

AU - Lal, Aditya

AU - El Khoury, Ramy

AU - Chen, Peng R.

AU - Savitz, Sean I.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Cell therapy is a novel investigational approach to enhance stroke recovery. Intra-arterial (IA) delivery has the potential advantage of selectively targeting cell therapies to the ischemic brain tissue. Over the past 10 years, IA cell delivery has been under investigation in patients with cardiac and peripheral vascular disease, and these studies have reported promising results. This article reviews the trial methodology and procedural details of these studies and discusses the rationale and challenges in designing IA cell therapy trials for ischemic stroke.

AB - Cell therapy is a novel investigational approach to enhance stroke recovery. Intra-arterial (IA) delivery has the potential advantage of selectively targeting cell therapies to the ischemic brain tissue. Over the past 10 years, IA cell delivery has been under investigation in patients with cardiac and peripheral vascular disease, and these studies have reported promising results. This article reviews the trial methodology and procedural details of these studies and discusses the rationale and challenges in designing IA cell therapy trials for ischemic stroke.

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Intra-arterial delivery of cell therapies for stroke

Abstract

ASJC Scopus subject areas

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