TY - GEN
T1 - Intracranial dual-mode IVUS and hyperthermia using circular arrays
AU - Patel, Vivek
AU - Light, Edward
AU - Herickhoff, Carl
AU - Palmeri, Mark
AU - Grant, Gerald
AU - Britz, Gavin
AU - Wilson, Christy
AU - Smith, Stephen
PY - 2011
Y1 - 2011
N2 - In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter through burr holes, for 20 MHz imaging, and 2) by testing a modified circular array for therapy potential with 18.5-MHz and 9.0 MHz CW excitation. The imaging transducer's performance was compared to our previous 9 MHz mechanical IVUS prototype. The therapy transducer was driven by CW electrical power, achieving temperature changes reaching +8°C at a depth of 2 mm in human glioblastoma tissue grown on the flank of a mouse. Further hyperthermia trials showed that resistive heating of the transducer was minimal producing a +2°C increase with CW excitation.
AB - In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter through burr holes, for 20 MHz imaging, and 2) by testing a modified circular array for therapy potential with 18.5-MHz and 9.0 MHz CW excitation. The imaging transducer's performance was compared to our previous 9 MHz mechanical IVUS prototype. The therapy transducer was driven by CW electrical power, achieving temperature changes reaching +8°C at a depth of 2 mm in human glioblastoma tissue grown on the flank of a mouse. Further hyperthermia trials showed that resistive heating of the transducer was minimal producing a +2°C increase with CW excitation.
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U2 - 10.1109/ULTSYM.2011.0542
DO - 10.1109/ULTSYM.2011.0542
M3 - Conference contribution
AN - SCOPUS:84869023589
SN - 9781457712531
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 2185
EP - 2188
BT - 2011 IEEE International Ultrasonics Symposium, IUS 2011
T2 - 2011 IEEE International Ultrasonics Symposium, IUS 2011
Y2 - 18 October 2011 through 21 October 2011
ER -