Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Hemamali Samaratunga; Brett Delahunt; Lars Egevad; John R. Srigley; Athanase Billis; David G. Bostwick; Philippe Camparo; Liang Cheng; David Clouston; James Denham; Bungo Furusato; Arndt Hartmann; Laura Jufe; James Kench; Diane N. Kenwright; Glen Kristiansen; Katia R.M. Leite; Gregory T. MacLennan; Jennifer Merrimen; Holger Moch; Jon Oxley; Chin Chen Pan; Gladell Paner; Jae Ro; Isabell A.M. Sesterhenn; Jonathan Shanks; Michelle Thunders; Toyonori Tsuzuki; Thomas Wheeler; John W. Yaxley; Murali Varma

doi:10.1016/j.pathol.2019.11.001

Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Hemamali Samaratunga, Brett Delahunt, Lars Egevad, John R. Srigley, Athanase Billis, David G. Bostwick, Philippe Camparo, Liang Cheng, David Clouston, James Denham, Bungo Furusato, Arndt Hartmann, Laura Jufe, James Kench, Diane N. Kenwright, Glen Kristiansen, Katia R.M. Leite, Gregory T. MacLennan, Jennifer Merrimen, Holger MochJon Oxley, Chin Chen Pan, Gladell Paner, Jae Ro, Isabell A.M. Sesterhenn, Jonathan Shanks, Michelle Thunders, Toyonori Tsuzuki, Thomas Wheeler, John W. Yaxley, Murali Varma

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

Original language	English (US)
Pages (from-to)	192-196
Number of pages	5
Journal	Pathology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.pathol.2019.11.001
State	Published - Feb 2020

Keywords

ISUP grade
Prostate adenocarcinoma
intraductal carcinoma of prostate
prognosis
Carcinoma, Ductal/pathology
Neoplasm Grading
Humans
Prostatic Neoplasms/pathology
Male

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.pathol.2019.11.001

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Samaratunga, H., Delahunt, B., Egevad, L., Srigley, J. R., Billis, A., Bostwick, D. G., Camparo, P., Cheng, L., Clouston, D., Denham, J., Furusato, B., Hartmann, A., Jufe, L., Kench, J., Kenwright, D. N., Kristiansen, G., Leite, K. R. M., MacLennan, G. T., Merrimen, J., ... Varma, M. (2020). Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology, 52(2), 192-196. https://doi.org/10.1016/j.pathol.2019.11.001

Samaratunga, H, Delahunt, B, Egevad, L, Srigley, JR, Billis, A, Bostwick, DG, Camparo, P, Cheng, L, Clouston, D, Denham, J, Furusato, B, Hartmann, A, Jufe, L, Kench, J, Kenwright, DN, Kristiansen, G, Leite, KRM, MacLennan, GT, Merrimen, J, Moch, H, Oxley, J, Pan, CC, Paner, G, Ro, J, Sesterhenn, IAM, Shanks, J, Thunders, M, Tsuzuki, T, Wheeler, T, Yaxley, JW & Varma, M 2020, 'Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded', Pathology, vol. 52, no. 2, pp. 192-196. https://doi.org/10.1016/j.pathol.2019.11.001

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abstract = "Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.",

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AU - Samaratunga, Hemamali

AU - Delahunt, Brett

AU - Egevad, Lars

AU - Srigley, John R.

AU - Billis, Athanase

AU - Bostwick, David G.

AU - Camparo, Philippe

AU - Cheng, Liang

AU - Clouston, David

AU - Denham, James

AU - Furusato, Bungo

AU - Hartmann, Arndt

AU - Jufe, Laura

AU - Kench, James

AU - Kenwright, Diane N.

AU - Kristiansen, Glen

AU - Leite, Katia R.M.

AU - MacLennan, Gregory T.

AU - Merrimen, Jennifer

AU - Moch, Holger

AU - Oxley, Jon

AU - Pan, Chin Chen

AU - Paner, Gladell

AU - Ro, Jae

AU - Sesterhenn, Isabell A.M.

AU - Shanks, Jonathan

AU - Thunders, Michelle

AU - Tsuzuki, Toyonori

AU - Wheeler, Thomas

AU - Yaxley, John W.

AU - Varma, Murali

PY - 2020/2

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N2 - Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

AB - Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

KW - ISUP grade

KW - Prostate adenocarcinoma

KW - intraductal carcinoma of prostate

KW - prognosis

KW - Carcinoma, Ductal/pathology

KW - Neoplasm Grading

KW - Humans

KW - Prostatic Neoplasms/pathology

KW - Male

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Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Abstract

Keywords

ASJC Scopus subject areas

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