Intraoperative fluorescence imaging in thoracic surgery

Andrew D. Newton; Jarrod D. Predina; Shuming Nie; Philip S. Low; Sunil Singhal

doi:10.1002/jso.25149

Intraoperative fluorescence imaging in thoracic surgery

Andrew D. Newton, Jarrod D. Predina, Shuming Nie, Philip S. Low, Sunil Singhal

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow^®) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

Original language	English (US)
Pages (from-to)	344-355
Number of pages	12
Journal	Journal of Surgical Oncology
Volume	118
Issue number	2
DOIs	https://doi.org/10.1002/jso.25149
State	Published - Aug 1 2018

Keywords

OTL38
indocyanine green (ICG)
intraoperative fluorescence imaging (IFI)
near-infrared (NIR) fluorescence imaging
thoracic surgery

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.25149

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@article{15634436704d4d30bc9bf0b685cb3e50,

title = "Intraoperative fluorescence imaging in thoracic surgery",

abstract = "Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow{\textregistered}) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.",

keywords = "OTL38, indocyanine green (ICG), intraoperative fluorescence imaging (IFI), near-infrared (NIR) fluorescence imaging, thoracic surgery",

author = "Newton, {Andrew D.} and Predina, {Jarrod D.} and Shuming Nie and Low, {Philip S.} and Sunil Singhal",

note = "Funding Information: S Singhal was supported by the NIH (R01 CA193556). Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = aug,

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doi = "10.1002/jso.25149",

language = "English (US)",

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T1 - Intraoperative fluorescence imaging in thoracic surgery

AU - Newton, Andrew D.

AU - Predina, Jarrod D.

AU - Nie, Shuming

AU - Low, Philip S.

AU - Singhal, Sunil

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow®) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

AB - Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow®) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

KW - OTL38

KW - indocyanine green (ICG)

KW - intraoperative fluorescence imaging (IFI)

KW - near-infrared (NIR) fluorescence imaging

KW - thoracic surgery

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DO - 10.1002/jso.25149

M3 - Review article

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SP - 344

EP - 355

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

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ER -

Intraoperative fluorescence imaging in thoracic surgery

Abstract

Keywords

ASJC Scopus subject areas

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