Isolation and analysis of renal bismuth inclusions

Robert E. Burr; A. M. Gotto; David L. Beaver

doi:10.1016/0041-008X(65)90044-X

Isolation and analysis of renal bismuth inclusions

Robert E. Burr, A. M. Gotto, David L. Beaver

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Typical bismuth inclusions were produced in rabbit kidney tubular cells. Histochemical examination of tissue fixed in 10% buffered neutral formalin and of fresh frozen tissue suggests that the inclusion consists of a lipid-carbohydrate-protein complex. In addition, the inclusions were obtained in a relatively pure state by ultracentrifugation and ultrasonic disintegration of kidney homogenate. Microchemical analysis of the pure inclusion fraction failed to reveal the presence of bismuth and furthers the argument that the body is a lipid-carbohydrate-protein structure.

Original language	English (US)
Pages (from-to)	588-591
Number of pages	4
Journal	Toxicology and Applied Pharmacology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0041-008X(65)90044-X
State	Published - Jul 1965

ASJC Scopus subject areas

Toxicology
Pharmacology

Access to Document

10.1016/0041-008X(65)90044-X

Cite this

@article{cdb4910f0e814fd2b9809591fa79c9ff,

title = "Isolation and analysis of renal bismuth inclusions",

abstract = "Typical bismuth inclusions were produced in rabbit kidney tubular cells. Histochemical examination of tissue fixed in 10% buffered neutral formalin and of fresh frozen tissue suggests that the inclusion consists of a lipid-carbohydrate-protein complex. In addition, the inclusions were obtained in a relatively pure state by ultracentrifugation and ultrasonic disintegration of kidney homogenate. Microchemical analysis of the pure inclusion fraction failed to reveal the presence of bismuth and furthers the argument that the body is a lipid-carbohydrate-protein structure.",

author = "Burr, {Robert E.} and Gotto, {A. M.} and Beaver, {David L.}",

note = "Funding Information: 1 This study was supported States Public Health Service. 2 Postdoctoral Research Scholar 3 Career Development Awardee Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1965",

month = jul,

doi = "10.1016/0041-008X(65)90044-X",

language = "English (US)",

volume = "7",

pages = "588--591",

journal = "Toxicology and Applied Pharmacology",

issn = "0041-008X",

publisher = "Academic Press",

number = "4",

}

TY - JOUR

T1 - Isolation and analysis of renal bismuth inclusions

AU - Burr, Robert E.

AU - Gotto, A. M.

AU - Beaver, David L.

N1 - Funding Information: 1 This study was supported States Public Health Service. 2 Postdoctoral Research Scholar 3 Career Development Awardee Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1965/7

Y1 - 1965/7

N2 - Typical bismuth inclusions were produced in rabbit kidney tubular cells. Histochemical examination of tissue fixed in 10% buffered neutral formalin and of fresh frozen tissue suggests that the inclusion consists of a lipid-carbohydrate-protein complex. In addition, the inclusions were obtained in a relatively pure state by ultracentrifugation and ultrasonic disintegration of kidney homogenate. Microchemical analysis of the pure inclusion fraction failed to reveal the presence of bismuth and furthers the argument that the body is a lipid-carbohydrate-protein structure.

AB - Typical bismuth inclusions were produced in rabbit kidney tubular cells. Histochemical examination of tissue fixed in 10% buffered neutral formalin and of fresh frozen tissue suggests that the inclusion consists of a lipid-carbohydrate-protein complex. In addition, the inclusions were obtained in a relatively pure state by ultracentrifugation and ultrasonic disintegration of kidney homogenate. Microchemical analysis of the pure inclusion fraction failed to reveal the presence of bismuth and furthers the argument that the body is a lipid-carbohydrate-protein structure.

UR - http://www.scopus.com/inward/record.url?scp=0013791183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013791183&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(65)90044-X

DO - 10.1016/0041-008X(65)90044-X

M3 - Article

C2 - 4284575

AN - SCOPUS:0013791183

SN - 0041-008X

VL - 7

SP - 588

EP - 591

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

IS - 4

ER -

Isolation and analysis of renal bismuth inclusions

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this