Learning from natural design for local anesthetic delivery

Qing Sun; Guangjun Nie

doi:10.1016/j.tips.2021.11.012

Learning from natural design for local anesthetic delivery

Research output: Contribution to journal › Article › peer-review

Abstract

There is a sizeable but unfilled need for drug delivery systems that prolong the duration of action and reduce the systemic toxicity of local anesthetics. Inspired by the interactions of anesthetics with their natural binding sites on sodium channels, Ji et al. designed self-assembled nanostructures that achieve specific delivery and sustained release of anesthetics.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.tips.2021.11.012
State	Published - Feb 2022

Keywords

controlled release system
local anesthetics
site-1 sodium channel blockers (S1SCBs)
specific delivery
supramolecular assembly
Anesthetics, Local/therapeutic use
Humans
Sodium Channels
Drug Delivery Systems

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.tips.2021.11.012

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abstract = "There is a sizeable but unfilled need for drug delivery systems that prolong the duration of action and reduce the systemic toxicity of local anesthetics. Inspired by the interactions of anesthetics with their natural binding sites on sodium channels, Ji et al. designed self-assembled nanostructures that achieve specific delivery and sustained release of anesthetics.",

keywords = "controlled release system, local anesthetics, site-1 sodium channel blockers (S1SCBs), specific delivery, supramolecular assembly, Anesthetics, Local/therapeutic use, Humans, Sodium Channels, Drug Delivery Systems",

author = "Qing Sun and Guangjun Nie",

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doi = "10.1016/j.tips.2021.11.012",

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AB - There is a sizeable but unfilled need for drug delivery systems that prolong the duration of action and reduce the systemic toxicity of local anesthetics. Inspired by the interactions of anesthetics with their natural binding sites on sodium channels, Ji et al. designed self-assembled nanostructures that achieve specific delivery and sustained release of anesthetics.

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KW - supramolecular assembly

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KW - Sodium Channels

KW - Drug Delivery Systems

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Learning from natural design for local anesthetic delivery

Abstract

Keywords

ASJC Scopus subject areas

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