@article{a0a95376a9f349f1a8755d674f611e62,
title = "Learning slopes in early-onset Alzheimer's disease",
abstract = "OBJECTIVE: Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight the sensitivity of learning slopes to discriminate disease severity in cognitively normal participants and those diagnosed with early-onset dementia with and without β-amyloid positivity. METHOD: Data from 310 participants in the Longitudinal Early-Onset Alzheimer's Disease Study (aged 41 to 65) were used to calculate learning slope metrics. Learning slopes among diagnostic groups were compared, and the relationships of slopes with standard memory measures were determined. RESULTS: Worse learning slopes were associated with more severe disease states, even after controlling for demographics, total learning, and cognitive severity. A particular metric—the learning ratio (LR)—outperformed other learning slope calculations across analyses. CONCLUSIONS: Learning slopes appear to be sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The LR may be the learning measure of choice for such analyses. Highlights: Learning is impaired in amyloid-positive EOAD, beyond cognitive severity scores alone. Amyloid-positive EOAD participants perform worse on learning slopes than amyloid-negative participants. Learning ratio appears to be the learning metric of choice for EOAD participants.",
keywords = "early-onset Alzheimer's disease, learning slopes, memory, Learning, Humans, Amyloid beta-Peptides, Alzheimer Disease/diagnosis, Amyloid, Amyloidogenic Proteins",
author = "Hammers, {Dustin B.} and S{\'a}ra Nemes and Taylor Diedrich and Ani Eloyan and Kala Kirby and Paul Aisen and Joel Kramer and Kelly Nudelman and Tatiana Foroud and Malia Rumbaugh and Alireza Atri and Day, {Gregory S.} and Ranjan Duara and Graff-Radford, {Neill R.} and Honig, {Lawrence S.} and Jones, {David T.} and Masdeu, {Joseph C.} and Mendez, {Mario F.} and Erik Musiek and Onyike, {Chiadi U.} and Meghan Riddle and Emily Rogalski and Steve Salloway and Sha, {Sharon J.} and Turner, {Raymond Scott} and Sandra Weintraub and Wingo, {Thomas S.} and Wolk, {David A.} and Bonnie Wong and Carrillo, {Maria C.} and Dickerson, {Bradford C.} and Rabinovici, {Gil D.} and Apostolova, {Liana G.}",
note = "Funding Information: We would like to thank all members of the LEADS Consortium, as well as the LEADS Clinical Outcomes group, and Constantine Gatsonis, PhD, for his statistical guidance. This study is generously supported by Alzheimer's Association AARG-22-926940, Alzheimer's Association LDRFP-21-818464, R56 AG057195, NIA U01AG6057195, NIA U24AG021886, Alzheimer's Association LEADS GENETICS-19-639372, NIA U01 AG016976, NIA P30 AG010133, NIA P50 AG008702, NIA P50 AG025688, NIA P50 AG005146, NIA P30 AG062421, NIA P30 AG062422, NIA P50 AG023501, NIA P30 AG010124, NIA P30AG066506, NIA P30 AG013854, NIA P50 AG005681, NIA P50AG047366, and NIA U24AG021886. Funding Information: We would like to thank all members of the LEADS Consortium, as well as the LEADS Clinical Outcomes group, and Constantine Gatsonis, PhD, for his statistical guidance. This study is generously supported by Alzheimer's Association AARG‐22‐926940, Alzheimer's Association LDRFP‐21‐818464, R56 AG057195, NIA U01AG6057195, NIA U24AG021886, Alzheimer's Association LEADS GENETICS‐19‐639372, NIA U01 AG016976, NIA P30 AG010133, NIA P50 AG008702, NIA P50 AG025688, NIA P50 AG005146, NIA P30 AG062421, NIA P30 AG062422, NIA P50 AG023501, NIA P30 AG010124, NIA P30AG066506, NIA P30 AG013854, NIA P50 AG005681, NIA P50AG047366, and NIA U24AG021886. Publisher Copyright: {\textcopyright} 2023 the Alzheimer's Association.",
year = "2023",
month = nov,
doi = "10.1002/alz.13159",
language = "English (US)",
volume = "19 Suppl 9",
pages = "S19--S28",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier",
number = "S9",
}