TY - JOUR
T1 - Left ventricular mass on positron emission tomography
T2 - Validation against cardiovascular magnetic resonance
AU - Malahfji, Maan
AU - Ahmed, Ahmed Ibrahim
AU - Han, Yushui
AU - Jung, Aaron K.
AU - Alnabelsi, Talal
AU - Nabi, Faisal
AU - Shah, Dipan J.
AU - Aljizeeri, Ahmed
AU - Poitrasson-Rivière, Alexis
AU - Ficaro, Edward
AU - Mahmarian, John J.
AU - Al-Mallah, Mouaz H.
N1 - Funding Information:
Dr. Al-Mallah receives support from the Houston Methodist Research Institute and Siemens. Dr. Malahfji receives support from the Houston Methodist Research Institute. No other potential conflicts of interest relevant to this article exist.
Publisher Copyright:
© 2021, American Society of Nuclear Cardiology.
PY - 2022/8
Y1 - 2022/8
N2 - BACKGROUND: Left ventricular hypertrophy (LVH) is an important clinical finding that is independently associated with mortality and cardiovascular events. We aimed to assess the interstudy variability of LV mass quantitation between PET and CMR.METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. LV mass on PET was compared against LV mass on CMR using several statistical measures of agreement.RESULTS: A total of 105 patients (mean age 60 ± 14 years, 67.6% male) were included. The median (interquartile range, IQR) duration between CMR and PET was 47 (11-154) days. The median (IQR) LV mass values were 168.0 g (126.0-202.0) on CMR and 174.0 g (150.0-212.0) with PET (absolute mean difference 29.42 ± 25.3). There was a good correlation (Spearman ρ = 0.81, P < 0.001; Intraclass Correlation Coefficient 0.78, 95% CI 0.70-0.85, P < 0.001) with moderate limits of agreement (95% limits of agreement - 63.78 to 83.7.) Results were consistent, albeit with moderate correlation, in subgroups of patients with LVH, in patients with myocardial infarction, in patients with LV ejection fraction < 50%, and those with limited image quality. LV mass on PET tended to be underestimated at high values compared to CMR.CONCLUSION: We demonstrate good correlation and reproducibility of LV mass quantitation by PET against the reference standard of CMR across a wide range of normal and diseased hearts with a tendency of PET to underestimate mass at higher mass values.
AB - BACKGROUND: Left ventricular hypertrophy (LVH) is an important clinical finding that is independently associated with mortality and cardiovascular events. We aimed to assess the interstudy variability of LV mass quantitation between PET and CMR.METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. LV mass on PET was compared against LV mass on CMR using several statistical measures of agreement.RESULTS: A total of 105 patients (mean age 60 ± 14 years, 67.6% male) were included. The median (interquartile range, IQR) duration between CMR and PET was 47 (11-154) days. The median (IQR) LV mass values were 168.0 g (126.0-202.0) on CMR and 174.0 g (150.0-212.0) with PET (absolute mean difference 29.42 ± 25.3). There was a good correlation (Spearman ρ = 0.81, P < 0.001; Intraclass Correlation Coefficient 0.78, 95% CI 0.70-0.85, P < 0.001) with moderate limits of agreement (95% limits of agreement - 63.78 to 83.7.) Results were consistent, albeit with moderate correlation, in subgroups of patients with LVH, in patients with myocardial infarction, in patients with LV ejection fraction < 50%, and those with limited image quality. LV mass on PET tended to be underestimated at high values compared to CMR.CONCLUSION: We demonstrate good correlation and reproducibility of LV mass quantitation by PET against the reference standard of CMR across a wide range of normal and diseased hearts with a tendency of PET to underestimate mass at higher mass values.
KW - CMR
KW - PET
KW - nuclear cardiac imaging
KW - Reproducibility of Results
KW - Prospective Studies
KW - Magnetic Resonance Spectroscopy
KW - Ventricular Function, Left
KW - Humans
KW - Middle Aged
KW - Male
KW - Hypertrophy, Left Ventricular/diagnostic imaging
KW - Magnetic Resonance Imaging, Cine/methods
KW - Stroke Volume
KW - Female
KW - Aged
KW - Positron-Emission Tomography/methods
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U2 - 10.1007/s12350-021-02537-6
DO - 10.1007/s12350-021-02537-6
M3 - Article
C2 - 33629247
AN - SCOPUS:85101495619
SN - 1071-3581
VL - 29
SP - 1632
EP - 1642
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 4
ER -