TY - JOUR
T1 - Leptin and incident cardiovascular disease
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Martin, Seth S.
AU - Blaha, Michael J.
AU - Muse, Evan D.
AU - Qasim, Atif N.
AU - Reilly, Muredach P.
AU - Blumenthal, Roger S.
AU - Nasir, Khurram
AU - Criqui, Michael H.
AU - McClelland, Robyn L.
AU - Hughes-Austin, Jan M.
AU - Allison, Matthew A.
N1 - Funding Information:
All authors had full access to the data and jointly decided to submit the manuscript for publication. This research was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . NIH sponsored MESA committees reviewed and approved the proposal, abstract, and manuscript from the present study. All authors had full access to the data and jointly decided to submit the manuscript for publication. SSM is supported by the Pollin Cardiovascular Prevention Fellowship, the Marie - Josée and Henry R. Kravis endowed fellowship, and a National Institutes of Health training grant ( T32HL07024 ).
Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p=0.46) and 0.91 (95% CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.
AB - Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p=0.46) and 0.91 (95% CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Heart failure
KW - Leptin
KW - Obesity
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U2 - 10.1016/j.atherosclerosis.2014.12.033
DO - 10.1016/j.atherosclerosis.2014.12.033
M3 - Article
C2 - 25574859
AN - SCOPUS:84920732376
SN - 0021-9150
VL - 239
SP - 67
EP - 72
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -