TY - JOUR
T1 - Lesions of anogenital mammary-like glands
T2 - Four cases including novel pathologic and immunohistochemical observations
AU - Arora, Komal
AU - El-Zaatari, Ziad M.
AU - Schwartz, Mary R.
AU - Ro, Jae Y.
N1 - Copyright © 2020 Elsevier Inc. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Anogenital mammary-like glands, formerly described as ectopic breast tissue, are currently considered to be normal histologic components of the anogenital region. Anogenital mammary-like glands can give rise to many lesions identical to counterparts in the native female breast. We describe four cases of such lesions, including fibroadenoma, gynecomastia-like hyperplasia, and ectopic mammary-type tissue with a spectrum of usual ductal hyperplasia, apocrine metaplasia, adenosis, and pseudolactational change. All four cases occurred in young women (ages 29–38) who presented with vulvar or perianal masses. Similar to previously reported cases, these lesions shared histologic and immunohistochemical characteristics identical to native female breast lesions. Novel findings in our cases included, (1) the first case of gynecomastia-like change to be reported in the perianal area of a female, (2) Immunohistochemical staining identifying a 3-layered epithelium characterized by a population of CK14 and CK5/6 positive and hormone receptor negative superficial luminal cells, and (3) diffuse, strong positivity for GATA3 in all cases. Our study adds to the literature on these rare lesions and highlights findings which may be useful in understanding the pathogenesis and improving the diagnosis of anogenital mammary-like gland lesions.
AB - Anogenital mammary-like glands, formerly described as ectopic breast tissue, are currently considered to be normal histologic components of the anogenital region. Anogenital mammary-like glands can give rise to many lesions identical to counterparts in the native female breast. We describe four cases of such lesions, including fibroadenoma, gynecomastia-like hyperplasia, and ectopic mammary-type tissue with a spectrum of usual ductal hyperplasia, apocrine metaplasia, adenosis, and pseudolactational change. All four cases occurred in young women (ages 29–38) who presented with vulvar or perianal masses. Similar to previously reported cases, these lesions shared histologic and immunohistochemical characteristics identical to native female breast lesions. Novel findings in our cases included, (1) the first case of gynecomastia-like change to be reported in the perianal area of a female, (2) Immunohistochemical staining identifying a 3-layered epithelium characterized by a population of CK14 and CK5/6 positive and hormone receptor negative superficial luminal cells, and (3) diffuse, strong positivity for GATA3 in all cases. Our study adds to the literature on these rare lesions and highlights findings which may be useful in understanding the pathogenesis and improving the diagnosis of anogenital mammary-like gland lesions.
KW - Anogenital mammary like glands
KW - Ectopic breast tissue
KW - Fibroadenoma
KW - GATA3
KW - Gynecomastia-like change
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U2 - 10.1016/j.anndiagpath.2020.151551
DO - 10.1016/j.anndiagpath.2020.151551
M3 - Article
C2 - 32592993
AN - SCOPUS:85087047541
SN - 1092-9134
VL - 47
SP - 151551
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
M1 - 151551
ER -