TY - JOUR
T1 - Management of increased intraocular pressure after cataract extraction
AU - Ruiz, R. S.
AU - Wilson, C. A.
AU - Musgrove, K. H.
AU - Prager, Thomas
N1 - Funding Information:
Accepted for publication Jan. 9, 1987 From the Hermann Eye Center, University of Texas Health Science Center, Houston, Texas. This study was supported in part by the Hermann Eye Fund. Reprint requests to Richard S. Ruiz, M.D., Hermann Eye Center, 1203 Ross Sterling Ave., Houston, TX 77030.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - We measured the change in intraocular pressure prospectively after extracapsular cataract extraction in 80 eyes after treatment with either pilocarpine gel, pilocarpine 4% solution, timolol 0.5% solution, or placebo. Intraocular pressure, pupil size, and anterior chamber cellular reaction were measured in a masked fashion on the first day after surgery. A significant increase in intraocular pressure was found in all groups postoperatively when compared with baseline values (P < .001). Eyes treated with pilocarpine gel had an average intraocular pressure increase of 4.2 ± 2.1 mm Hg (mean ± 1 S.E.), eyes treated with pilocarpine 4% eyedrops had an average increase of 9.8 ± 2.8 mm Hg, and eyes treated with timolol demonstrated an intraocular pressure increase of 8.25 ± 3.19. The intraocular pressure in untreated eyes (controls) increased by an average of 12.9 ± 2.7 mm Hg. Only the difference in intraocular pressure change between the eyes treated with pilocarpine gel and control eyes was statistically significant (P = .025). Postsurgical intraocular pressure exceeding 25 mm Hg was observed in three of 20 pilocarpine gel treated eyes (15%) and 11 of 20 control eyes (55%). Pilocarpine treatment was not associated with noticeable changes in intraocular inflammatory response, nor were significant ocular or systemic adverse reactions observed. A single administration of pilocarpine gel is effective in reducing increased intraocular pressure for the first 24 hours after extracapsular cataract extraction.
AB - We measured the change in intraocular pressure prospectively after extracapsular cataract extraction in 80 eyes after treatment with either pilocarpine gel, pilocarpine 4% solution, timolol 0.5% solution, or placebo. Intraocular pressure, pupil size, and anterior chamber cellular reaction were measured in a masked fashion on the first day after surgery. A significant increase in intraocular pressure was found in all groups postoperatively when compared with baseline values (P < .001). Eyes treated with pilocarpine gel had an average intraocular pressure increase of 4.2 ± 2.1 mm Hg (mean ± 1 S.E.), eyes treated with pilocarpine 4% eyedrops had an average increase of 9.8 ± 2.8 mm Hg, and eyes treated with timolol demonstrated an intraocular pressure increase of 8.25 ± 3.19. The intraocular pressure in untreated eyes (controls) increased by an average of 12.9 ± 2.7 mm Hg. Only the difference in intraocular pressure change between the eyes treated with pilocarpine gel and control eyes was statistically significant (P = .025). Postsurgical intraocular pressure exceeding 25 mm Hg was observed in three of 20 pilocarpine gel treated eyes (15%) and 11 of 20 control eyes (55%). Pilocarpine treatment was not associated with noticeable changes in intraocular inflammatory response, nor were significant ocular or systemic adverse reactions observed. A single administration of pilocarpine gel is effective in reducing increased intraocular pressure for the first 24 hours after extracapsular cataract extraction.
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U2 - 10.1016/S0002-9394(14)74269-2
DO - 10.1016/S0002-9394(14)74269-2
M3 - Article
C2 - 3551618
AN - SCOPUS:0023092631
SN - 0002-9394
VL - 103
SP - 487
EP - 491
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -