Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics

Inge J. van den Hoogen; Alexander R. van Rosendael; Fay Y. Lin; Umberto Gianni; Daniele Andreini; Mouaz H. Al-Mallah; Matthew J. Budoff; Filippo Cademartiri; Kavitha Chinnaiyan; Jung Hyun Choi; Edoardo Conte; Hugo Marques; Pedro de Araújo Gonçalves; Ilan Gottlieb; Martin Hadamitzky; Jonathon Leipsic; Erica Maffei; Gianluca Pontone; Sanghoon Shin; Yong Jin Kim; Byoung Kwon Lee; Eun Ju Chun; Ji Min Sung; Sang Eun Lee; Daniel S. Berman; Renu Virmani; Habib Samady; Peter H. Stone; Jagat Narula; Hyuk Jae Chang; James K. Min; Leslee J. Shaw; Jeroen J. Bax

doi:10.1093/ehjci/jeab138

Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics

Inge J. van den Hoogen, Alexander R. van Rosendael, Fay Y. Lin, Umberto Gianni, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon Leipsic, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong Jin KimByoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang Eun Lee, Daniel S. Berman, Renu Virmani, Habib Samady, Peter H. Stone, Jagat Narula, Hyuk Jae Chang, James K. Min, Leslee J. Shaw, Jeroen J. Bax

Research output: Contribution to journal › Article › peer-review

Abstract

Aims The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). ................................................................................................................................................................................................... Methods From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated and results serial CCTA (median interscan interval = 3.3 years), we quantitatively measured coronary plaque, vessel, and lumen volumes on both scans. Primary outcome was the per-segment change in coronary vessel and lumen volume from a change in plaque volume, focusing on arterial remodelling. Multivariate generalized estimating equations including statins were calculated comparing associations between groups of baseline percent atheroma volume (PAV) and location within the coronary artery tree. From 1245 patients (mean age 61 ± 9 years, 39% women), a total of 5721 segments were analysed. For each 1.00 mm³ increase in plaque volume, the vessel volume increased by 0.71 mm³ [95% confidence interval (CI) 0.63 to 0.79 mm³, P < 0.001] with a corresponding reduction in lumen volume by 0.29 mm³ (95% CI -0.37 to -0.21 mm³, P < 0.001). Serial 3D arterial remodelling and luminal narrowing was similar in segments with low and high baseline PAV (P >_ 0.496). No differences were observed between left main and non-left main segments, proximal and distal segments and side branch and non-side branch segments (P >_ 0.281). ................................................................................................................................................................................................... Conclusions Over time, atherosclerotic coronary plaque reveals prominent outward arterial remodelling that co-occurs with modest luminal narrowing. These findings provide additional insight into the compensatory mechanisms involved in the progression of coronary atherosclerosis.

Original language	English (US)
Pages (from-to)	1336-1344
Number of pages	9
Journal	European Heart Journal Cardiovascular Imaging
Volume	23
Issue number	10
DOIs	https://doi.org/10.1093/ehjci/jeab138
State	Published - Oct 1 2022

Keywords

atherosclerosis
coronary arterial remodelling
coronary computed tomography angiography
plaque progression

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1093/ehjci/jeab138

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van den Hoogen, I. J., van Rosendael, A. R., Lin, F. Y., Gianni, U., Andreini, D., Al-Mallah, M. H., Budoff, M. J., Cademartiri, F., Chinnaiyan, K., Choi, J. H., Conte, E., Marques, H., de Araújo Gonçalves, P., Gottlieb, I., Hadamitzky, M., Leipsic, J., Maffei, E., Pontone, G., Shin, S., ... Bax, J. J. (2022). Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics. European Heart Journal Cardiovascular Imaging, 23(10), 1336-1344. https://doi.org/10.1093/ehjci/jeab138

van den Hoogen, IJ, van Rosendael, AR, Lin, FY, Gianni, U, Andreini, D, Al-Mallah, MH, Budoff, MJ, Cademartiri, F, Chinnaiyan, K, Choi, JH, Conte, E, Marques, H, de Araújo Gonçalves, P, Gottlieb, I, Hadamitzky, M, Leipsic, J, Maffei, E, Pontone, G, Shin, S, Kim, YJ, Lee, BK, Chun, EJ, Sung, JM, Lee, SE, Berman, DS, Virmani, R, Samady, H, Stone, PH, Narula, J, Chang, HJ, Min, JK, Shaw, LJ & Bax, JJ 2022, 'Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics', European Heart Journal Cardiovascular Imaging, vol. 23, no. 10, pp. 1336-1344. https://doi.org/10.1093/ehjci/jeab138

@article{c47776600f0844a1abcf1ab16cc4888a,

title = "Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics",

abstract = "Aims The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). ................................................................................................................................................................................................... Methods From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated and results serial CCTA (median interscan interval = 3.3 years), we quantitatively measured coronary plaque, vessel, and lumen volumes on both scans. Primary outcome was the per-segment change in coronary vessel and lumen volume from a change in plaque volume, focusing on arterial remodelling. Multivariate generalized estimating equations including statins were calculated comparing associations between groups of baseline percent atheroma volume (PAV) and location within the coronary artery tree. From 1245 patients (mean age 61 ± 9 years, 39% women), a total of 5721 segments were analysed. For each 1.00 mm3 increase in plaque volume, the vessel volume increased by 0.71 mm3 [95% confidence interval (CI) 0.63 to 0.79 mm3, P < 0.001] with a corresponding reduction in lumen volume by 0.29 mm3 (95% CI -0.37 to -0.21 mm3, P < 0.001). Serial 3D arterial remodelling and luminal narrowing was similar in segments with low and high baseline PAV (P >_ 0.496). No differences were observed between left main and non-left main segments, proximal and distal segments and side branch and non-side branch segments (P >_ 0.281). ................................................................................................................................................................................................... Conclusions Over time, atherosclerotic coronary plaque reveals prominent outward arterial remodelling that co-occurs with modest luminal narrowing. These findings provide additional insight into the compensatory mechanisms involved in the progression of coronary atherosclerosis.",

keywords = "atherosclerosis, coronary arterial remodelling, coronary computed tomography angiography, plaque progression",

author = "{van den Hoogen}, {Inge J.} and {van Rosendael}, {Alexander R.} and Lin, {Fay Y.} and Umberto Gianni and Daniele Andreini and Al-Mallah, {Mouaz H.} and Budoff, {Matthew J.} and Filippo Cademartiri and Kavitha Chinnaiyan and Choi, {Jung Hyun} and Edoardo Conte and Hugo Marques and {de Ara{\'u}jo Gon{\c c}alves}, Pedro and Ilan Gottlieb and Martin Hadamitzky and Jonathon Leipsic and Erica Maffei and Gianluca Pontone and Sanghoon Shin and Kim, {Yong Jin} and Lee, {Byoung Kwon} and Chun, {Eun Ju} and Sung, {Ji Min} and Lee, {Sang Eun} and Berman, {Daniel S.} and Renu Virmani and Habib Samady and Stone, {Peter H.} and Jagat Narula and Chang, {Hyuk Jae} and Min, {James K.} and Shaw, {Leslee J.} and Bax, {Jeroen J.}",

note = "Funding Information: This work was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (MSIT) (2012027176). The study was also funded in part by a generous gift from the Dalio Institute of Cardiovascular Imaging (New York, NY) and the Michael Wolk Foundation (New York, NY). Publisher Copyright: All rights reserved. VC The Author(s) 2021.",

year = "2022",

month = oct,

day = "1",

doi = "10.1093/ehjci/jeab138",

language = "English (US)",

volume = "23",

pages = "1336--1344",

journal = "European Heart Journal Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics

AU - van den Hoogen, Inge J.

AU - van Rosendael, Alexander R.

AU - Lin, Fay Y.

AU - Gianni, Umberto

AU - Andreini, Daniele

AU - Al-Mallah, Mouaz H.

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Chinnaiyan, Kavitha

AU - Choi, Jung Hyun

AU - Conte, Edoardo

AU - Marques, Hugo

AU - de Araújo Gonçalves, Pedro

AU - Gottlieb, Ilan

AU - Hadamitzky, Martin

AU - Leipsic, Jonathon

AU - Maffei, Erica

AU - Pontone, Gianluca

AU - Shin, Sanghoon

AU - Kim, Yong Jin

AU - Lee, Byoung Kwon

AU - Chun, Eun Ju

AU - Sung, Ji Min

AU - Lee, Sang Eun

AU - Berman, Daniel S.

AU - Virmani, Renu

AU - Samady, Habib

AU - Stone, Peter H.

AU - Narula, Jagat

AU - Chang, Hyuk Jae

AU - Min, James K.

AU - Shaw, Leslee J.

AU - Bax, Jeroen J.

N1 - Funding Information: This work was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (MSIT) (2012027176). The study was also funded in part by a generous gift from the Dalio Institute of Cardiovascular Imaging (New York, NY) and the Michael Wolk Foundation (New York, NY). Publisher Copyright: All rights reserved. VC The Author(s) 2021.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Aims The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). ................................................................................................................................................................................................... Methods From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated and results serial CCTA (median interscan interval = 3.3 years), we quantitatively measured coronary plaque, vessel, and lumen volumes on both scans. Primary outcome was the per-segment change in coronary vessel and lumen volume from a change in plaque volume, focusing on arterial remodelling. Multivariate generalized estimating equations including statins were calculated comparing associations between groups of baseline percent atheroma volume (PAV) and location within the coronary artery tree. From 1245 patients (mean age 61 ± 9 years, 39% women), a total of 5721 segments were analysed. For each 1.00 mm3 increase in plaque volume, the vessel volume increased by 0.71 mm3 [95% confidence interval (CI) 0.63 to 0.79 mm3, P < 0.001] with a corresponding reduction in lumen volume by 0.29 mm3 (95% CI -0.37 to -0.21 mm3, P < 0.001). Serial 3D arterial remodelling and luminal narrowing was similar in segments with low and high baseline PAV (P >_ 0.496). No differences were observed between left main and non-left main segments, proximal and distal segments and side branch and non-side branch segments (P >_ 0.281). ................................................................................................................................................................................................... Conclusions Over time, atherosclerotic coronary plaque reveals prominent outward arterial remodelling that co-occurs with modest luminal narrowing. These findings provide additional insight into the compensatory mechanisms involved in the progression of coronary atherosclerosis.

AB - Aims The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). ................................................................................................................................................................................................... Methods From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated and results serial CCTA (median interscan interval = 3.3 years), we quantitatively measured coronary plaque, vessel, and lumen volumes on both scans. Primary outcome was the per-segment change in coronary vessel and lumen volume from a change in plaque volume, focusing on arterial remodelling. Multivariate generalized estimating equations including statins were calculated comparing associations between groups of baseline percent atheroma volume (PAV) and location within the coronary artery tree. From 1245 patients (mean age 61 ± 9 years, 39% women), a total of 5721 segments were analysed. For each 1.00 mm3 increase in plaque volume, the vessel volume increased by 0.71 mm3 [95% confidence interval (CI) 0.63 to 0.79 mm3, P < 0.001] with a corresponding reduction in lumen volume by 0.29 mm3 (95% CI -0.37 to -0.21 mm3, P < 0.001). Serial 3D arterial remodelling and luminal narrowing was similar in segments with low and high baseline PAV (P >_ 0.496). No differences were observed between left main and non-left main segments, proximal and distal segments and side branch and non-side branch segments (P >_ 0.281). ................................................................................................................................................................................................... Conclusions Over time, atherosclerotic coronary plaque reveals prominent outward arterial remodelling that co-occurs with modest luminal narrowing. These findings provide additional insight into the compensatory mechanisms involved in the progression of coronary atherosclerosis.

KW - atherosclerosis

KW - coronary arterial remodelling

KW - coronary computed tomography angiography

KW - plaque progression

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U2 - 10.1093/ehjci/jeab138

DO - 10.1093/ehjci/jeab138

M3 - Article

C2 - 34468717

AN - SCOPUS:85138128360

SN - 2047-2404

VL - 23

SP - 1336

EP - 1344

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

IS - 10

ER -

Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics

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