TY - JOUR
T1 - Mechanisms of disease
T2 - is mitochondrial function altered in heart failure?
AU - Hamilton, Dale J.
PY - 2013
Y1 - 2013
N2 - The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.
AB - The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.
UR - http://www.scopus.com/inward/record.url?scp=84891706291&partnerID=8YFLogxK
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U2 - 10.14797/mdcj-9-1-44
DO - 10.14797/mdcj-9-1-44
M3 - Review article
C2 - 23519321
AN - SCOPUS:84891706291
SN - 1947-6094
VL - 9
SP - 44
EP - 48
JO - Methodist DeBakey cardiovascular journal
JF - Methodist DeBakey cardiovascular journal
IS - 1
ER -