TY - JOUR
T1 - Mitochondria
T2 - Sensors and mediators of innate immune receptor signaling
AU - Cloonan, Suzanne M.
AU - Choi, Augustine M.K.
PY - 2013/6
Y1 - 2013/6
N2 - By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.
AB - By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.
UR - http://www.scopus.com/inward/record.url?scp=84881548201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881548201&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2013.05.005
DO - 10.1016/j.mib.2013.05.005
M3 - Review article
C2 - 23757367
AN - SCOPUS:84881548201
SN - 1369-5274
VL - 16
SP - 327
EP - 338
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 3
ER -